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APOE gene and neuropsychiatric disorders and endophenotypes: A comprehensive review
The Apolipoprotein E (APOE) gene is one of the main candidates in neuropsychiatric genetics, with hundreds of studies carried out in order to explore the possible role of polymorphisms in the APOE gene in a large number of neurological diseases, psychiatric disorders, and related endophenotypes. In...
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| Published in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2018-03, Vol.177 (2), p.126-142 |
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| Main Authors: | , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c3646-3b14aa28e77c66e4679f311a2878c02be4011d4f829fe0a53b15763aa84bc2533 |
| container_end_page | 142 |
| container_issue | 2 |
| container_start_page | 126 |
| container_title | American journal of medical genetics. Part B, Neuropsychiatric genetics |
| container_volume | 177 |
| creator | Forero, Diego A. López‐León, Sandra González‐Giraldo, Yeimy Dries, Daniel R. Pereira‐Morales, Angela J. Jiménez, Karen M. Franco‐Restrepo, Juan E. |
| description | The Apolipoprotein E (APOE) gene is one of the main candidates in neuropsychiatric genetics, with hundreds of studies carried out in order to explore the possible role of polymorphisms in the APOE gene in a large number of neurological diseases, psychiatric disorders, and related endophenotypes. In the current article, we provide a comprehensive review of the structural and functional aspects of the APOE gene and its relationship with brain disorders. Evidence from genome‐wide association studies and meta‐analyses shows that the APOE gene has been significantly associated with several neurodegenerative disorders. Cellular and animal models show growing evidence of the key role of APOE in mechanisms of brain plasticity and behavior. Future analyses of the APOE gene might find a possible role in other neurological diseases and psychiatric disorders and related endophenotypes. © 2016 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/ajmg.b.32516 |
| format | article |
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Part B, Neuropsychiatric genetics</title><addtitle>Am J Med Genet B Neuropsychiatr Genet</addtitle><description>The Apolipoprotein E (APOE) gene is one of the main candidates in neuropsychiatric genetics, with hundreds of studies carried out in order to explore the possible role of polymorphisms in the APOE gene in a large number of neurological diseases, psychiatric disorders, and related endophenotypes. In the current article, we provide a comprehensive review of the structural and functional aspects of the APOE gene and its relationship with brain disorders. Evidence from genome‐wide association studies and meta‐analyses shows that the APOE gene has been significantly associated with several neurodegenerative disorders. Cellular and animal models show growing evidence of the key role of APOE in mechanisms of brain plasticity and behavior. Future analyses of the APOE gene might find a possible role in other neurological diseases and psychiatric disorders and related endophenotypes. © 2016 Wiley Periodicals, Inc.</description><subject>Animal models</subject><subject>Animals</subject><subject>Apolipoprotein E</subject><subject>Apolipoproteins E - genetics</subject><subject>Apolipoproteins E - metabolism</subject><subject>Behavior disorders</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>candidate gene</subject><subject>Centenarians</subject><subject>Endophenotypes</subject><subject>Genetics</subject><subject>Genome-wide association studies</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Humans</subject><subject>Mental disorders</subject><subject>Mental Disorders - genetics</subject><subject>Mental Disorders - metabolism</subject><subject>Mental Disorders - pathology</subject><subject>meta‐analyses</subject><subject>Neurodegenerative diseases</subject><subject>Neurodegenerative Diseases - genetics</subject><subject>Neurodegenerative Diseases - metabolism</subject><subject>Neurodegenerative Diseases - pathology</subject><subject>neurogenetics</subject><subject>Neurological diseases</subject><subject>neuropsychiatric genetics</subject><subject>Polymorphism, Genetic</subject><subject>Structure-function relationships</subject><issn>1552-4841</issn><issn>1552-485X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1Lw0AQhhdRtFZvniXgxYOt-53EW5ValYqCCt6WzWaiKU027jaW_Hu3rXrw4GmGdx5ehgehI4KHBGN6rmfV2zAbMiqI3EI9IgQd8ES8bv_unOyhfe9nGDMs4ngX7dE45UzItIeeRo8P4-gNaoh0nUc1tM42vjPvpV640kR56a3Lwfn1GercNu9Q20XXgL-IRpGxVeMgRL78hMjBZwnLA7RT6LmHw-_ZRy_X4-erm8H0YXJ7NZoODJNcDlhGuNY0gTg2UgKXcVowQkISJwbTDDgmJOdFQtMCsBaBF7FkWic8M1Qw1kenm97G2Y8W_EJVpTcwn-sabOsVSQSVkhIpAnryB53Z1tXhO0UxJokMPtJAnW0o46z3DgrVuLLSrlMEq5VstZKtMrWWHfDj79I2qyD_hX_sBoBvgGU5h-7fMjW6u59cbnq_AIeUik8</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Forero, Diego A.</creator><creator>López‐León, Sandra</creator><creator>González‐Giraldo, Yeimy</creator><creator>Dries, Daniel R.</creator><creator>Pereira‐Morales, Angela J.</creator><creator>Jiménez, Karen M.</creator><creator>Franco‐Restrepo, Juan E.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201803</creationdate><title>APOE gene and neuropsychiatric disorders and endophenotypes: A comprehensive review</title><author>Forero, Diego A. ; 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| ispartof | American journal of medical genetics. Part B, Neuropsychiatric genetics, 2018-03, Vol.177 (2), p.126-142 |
| issn | 1552-4841 1552-485X |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Animal models Animals Apolipoprotein E Apolipoproteins E - genetics Apolipoproteins E - metabolism Behavior disorders Brain - metabolism Brain - pathology candidate gene Centenarians Endophenotypes Genetics Genome-wide association studies Genome-Wide Association Study Genomes Genotype Humans Mental disorders Mental Disorders - genetics Mental Disorders - metabolism Mental Disorders - pathology meta‐analyses Neurodegenerative diseases Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology neurogenetics Neurological diseases neuropsychiatric genetics Polymorphism, Genetic Structure-function relationships |
| title | APOE gene and neuropsychiatric disorders and endophenotypes: A comprehensive review |
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