The association of sociodemographic and objectively-assessed disease variables with fatigue in systemic sclerosis: an analysis of 785 Canadian Scleroderma Research Group Registry patients

Fatigue is prevalent among patients with systemic sclerosis (SSc). To date, studies investigating fatigue in SSc have been hampered by the instruments used to measure fatigue in SSc and have included patient-reported rather than objectively-rated measures of disease. The Functional Assessment of Chr...

Full description

Saved in:
Bibliographic Details
Published in:Clinical rheumatology 2017-02, Vol.36 (2), p.373-379
Main Authors: Levis, Brooke, Kwakkenbos, Linda, Hudson, Marie, Baron, Murray, Thombs, Brett D.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Canada
Chronic Disease
Comorbidity
Fatigue - complications
Fatigue - diagnosis
Fatigue - epidemiology
Female
Humans
Linear Models
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Original Article
Registries
Rheumatology
Rheumatology - methods
Scleroderma, Systemic - complications
Scleroderma, Systemic - diagnosis
Scleroderma, Systemic - epidemiology
Severity of Illness Index
Social Class
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fatigue is prevalent among patients with systemic sclerosis (SSc). To date, studies investigating fatigue in SSc have been hampered by the instruments used to measure fatigue in SSc and have included patient-reported rather than objectively-rated measures of disease. The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale is a validated measure for assessing fatigue in SSc that, compared to other instruments, provides good coverage of the full range of the fatigue spectrum. The objective of this study was to assess sociodemographic and objectively-rated disease-related associates of fatigue, as measured by the FACIT-F, in a large sample of patients with SSc. Fatigue was assessed using the FACIT-F scale. Disease severity was assessed using Medsger’s severity scale. Multivariable linear regression was performed to assess the independent associations between sociodemographic and medical variables and fatigue. Among 785 patients, the mean FACIT-F score was 32.2 (SD = 12.1). Being age 40–49 (reference = 60+; standardized regression coefficient ( β ) = −0.11), less than post-secondary education ( β  = 0.07), having more medical comorbidities ( β  = −0.11) and more severe muscle ( β  = −0.10), gastrointestinal ( β  = −0.15), lung ( β  = −0.13), and general system disease severity ( β  = −0.13) were independently associated with more fatigue ( p  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-016-3501-9