Heterogeneity of Brain Ribosomal Genes Expression Following Positive Fighting Experience in Male Mice as Revealed by RNA-Seq

Repeated positive fighting experience in daily agonistic interactions is accompanied by changes of brain neurotransmitter activity and genes’ expression in male mice. This paper is focused on the analysis of ribosomal genes expression data as revealed by whole-transcriptome analysis (RNA-Seq) in fiv...

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Bibliographic Details
Published in:Molecular neurobiology 2018-01, Vol.55 (1), p.390-401
Main Authors: Smagin, Dmitry A, Kovalenko, Irina L, Galyamina, Anna G, Orlov, Yuriy L, Babenko, Vladimir N, Kudryavtseva, Natalia N
Format: Article
Language:English
Subjects:
Aggression - physiology
Animals
Biomedical and Life Sciences
Biomedicine
Brain - physiology
Cell Biology
Fighting
Gene Expression
Hypothalamus
Male
Mesencephalon
Mice
Mice, Inbred C57BL
Neostriatum
Neurobiology
Neurology
Neurosciences
Raphe nuclei
Ribonucleic acid
Ribosomal Proteins - biosynthesis
Ribosomal Proteins - genetics
RNA
Rodents
Sequence Analysis, RNA - methods
Ventral tegmentum
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Summary:Repeated positive fighting experience in daily agonistic interactions is accompanied by changes of brain neurotransmitter activity and genes’ expression in male mice. This paper is focused on the analysis of ribosomal genes expression data as revealed by whole-transcriptome analysis (RNA-Seq) in five brain regions of male mice with long repeated experience of aggression accompanied by wins (winners). Downregulation of most Rps , Rpl , Mrps , and Mrpl genes was found in the midbrain raphe nuclei and striatum and upregulation—in the hippocampus and hypothalamus of the winners. There were no changes in ribosomal gene expression in the ventral tegmental area. The data allow considering the alteration in ribosomal gene expression as an animal model of ribosomal dysfunction developed under positive fighting experience in male mice.
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-016-0327-z