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Heterogeneity of Brain Ribosomal Genes Expression Following Positive Fighting Experience in Male Mice as Revealed by RNA-Seq
Repeated positive fighting experience in daily agonistic interactions is accompanied by changes of brain neurotransmitter activity and genes’ expression in male mice. This paper is focused on the analysis of ribosomal genes expression data as revealed by whole-transcriptome analysis (RNA-Seq) in fiv...
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| Published in: | Molecular neurobiology 2018-01, Vol.55 (1), p.390-401 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c442t-5e1dbc73c0bfc1088e7adfc9b5fd4a6f01a371fc2ecbeaba0dd0a2ed5f78e51a3 |
| container_end_page | 401 |
| container_issue | 1 |
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| container_title | Molecular neurobiology |
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| creator | Smagin, Dmitry A Kovalenko, Irina L Galyamina, Anna G Orlov, Yuriy L Babenko, Vladimir N Kudryavtseva, Natalia N |
| description | Repeated positive fighting experience in daily agonistic interactions is accompanied by changes of brain neurotransmitter activity and genes’ expression in male mice. This paper is focused on the analysis of ribosomal genes expression data as revealed by whole-transcriptome analysis (RNA-Seq) in five brain regions of male mice with long repeated experience of aggression accompanied by wins (winners). Downregulation of most
Rps
,
Rpl
,
Mrps
, and
Mrpl
genes was found in the midbrain raphe nuclei and striatum and upregulation—in the hippocampus and hypothalamus of the winners. There were no changes in ribosomal gene expression in the ventral tegmental area. The data allow considering the alteration in ribosomal gene expression as an animal model of ribosomal dysfunction developed under positive fighting experience in male mice. |
| doi_str_mv | 10.1007/s12035-016-0327-z |
| format | article |
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Rps
,
Rpl
,
Mrps
, and
Mrpl
genes was found in the midbrain raphe nuclei and striatum and upregulation—in the hippocampus and hypothalamus of the winners. There were no changes in ribosomal gene expression in the ventral tegmental area. The data allow considering the alteration in ribosomal gene expression as an animal model of ribosomal dysfunction developed under positive fighting experience in male mice.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-016-0327-z</identifier><identifier>PMID: 27957683</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aggression - physiology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Brain - physiology ; Cell Biology ; Fighting ; Gene Expression ; Hypothalamus ; Male ; Mesencephalon ; Mice ; Mice, Inbred C57BL ; Neostriatum ; Neurobiology ; Neurology ; Neurosciences ; Raphe nuclei ; Ribonucleic acid ; Ribosomal Proteins - biosynthesis ; Ribosomal Proteins - genetics ; RNA ; Rodents ; Sequence Analysis, RNA - methods ; Ventral tegmentum</subject><ispartof>Molecular neurobiology, 2018-01, Vol.55 (1), p.390-401</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Molecular Neurobiology is a copyright of Springer, (2016). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-5e1dbc73c0bfc1088e7adfc9b5fd4a6f01a371fc2ecbeaba0dd0a2ed5f78e51a3</citedby><cites>FETCH-LOGICAL-c442t-5e1dbc73c0bfc1088e7adfc9b5fd4a6f01a371fc2ecbeaba0dd0a2ed5f78e51a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27957683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smagin, Dmitry A</creatorcontrib><creatorcontrib>Kovalenko, Irina L</creatorcontrib><creatorcontrib>Galyamina, Anna G</creatorcontrib><creatorcontrib>Orlov, Yuriy L</creatorcontrib><creatorcontrib>Babenko, Vladimir N</creatorcontrib><creatorcontrib>Kudryavtseva, Natalia N</creatorcontrib><title>Heterogeneity of Brain Ribosomal Genes Expression Following Positive Fighting Experience in Male Mice as Revealed by RNA-Seq</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>Repeated positive fighting experience in daily agonistic interactions is accompanied by changes of brain neurotransmitter activity and genes’ expression in male mice. This paper is focused on the analysis of ribosomal genes expression data as revealed by whole-transcriptome analysis (RNA-Seq) in five brain regions of male mice with long repeated experience of aggression accompanied by wins (winners). Downregulation of most
Rps
,
Rpl
,
Mrps
, and
Mrpl
genes was found in the midbrain raphe nuclei and striatum and upregulation—in the hippocampus and hypothalamus of the winners. There were no changes in ribosomal gene expression in the ventral tegmental area. The data allow considering the alteration in ribosomal gene expression as an animal model of ribosomal dysfunction developed under positive fighting experience in male mice.</description><subject>Aggression - physiology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - physiology</subject><subject>Cell Biology</subject><subject>Fighting</subject><subject>Gene Expression</subject><subject>Hypothalamus</subject><subject>Male</subject><subject>Mesencephalon</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Neostriatum</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Raphe nuclei</subject><subject>Ribonucleic acid</subject><subject>Ribosomal Proteins - biosynthesis</subject><subject>Ribosomal Proteins - genetics</subject><subject>RNA</subject><subject>Rodents</subject><subject>Sequence Analysis, RNA - methods</subject><subject>Ventral tegmentum</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kUFvEzEQhS0EoqHwA7ggS1x6MYy967X3WKqmRWoBhfZseb3j4GqzTu1NIRU_vo5SQELqaTTzvnlj-RHylsMHDqA-Zi6gkgx4w6ASit0_IzMuZcs41-I5mYFuK6aaWh-QVznfAAjBQb0kB0K1UjW6mpHf5zhhikscMUxbGj39lGwY6SJ0MceVHehZkTI9_bVOmHOII53HYYg_w7ik32IOU7hDOg_LH9NuUjBMAUeHtJhc2gHpZSiNzXSBd1j6nnZbuvhyzL7j7Wvywtsh45vHekiu56dXJ-fs4uvZ55PjC-bqWkxMIu87pyoHnXcctEZle-_aTvq-to0HbivFvRPoOrSdhb4HK7CXXmmURTwkR3vfdYq3G8yTWYXscBjsiHGTDddSNE0LrS7o-__Qm7hJY3md2f1dq3VdQaH4nnIp5pzQm3UKK5u2hoPZRWP20ZgSjdlFY-7LzrtH5023wv7vxp8sCiD2QC7SuMT07_TTrg-SCZvL</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Smagin, Dmitry A</creator><creator>Kovalenko, Irina L</creator><creator>Galyamina, Anna G</creator><creator>Orlov, Yuriy L</creator><creator>Babenko, Vladimir N</creator><creator>Kudryavtseva, Natalia N</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180101</creationdate><title>Heterogeneity of Brain Ribosomal Genes Expression Following Positive Fighting Experience in Male Mice as Revealed by RNA-Seq</title><author>Smagin, Dmitry A ; Kovalenko, Irina L ; Galyamina, Anna G ; Orlov, Yuriy L ; Babenko, Vladimir N ; Kudryavtseva, Natalia N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-5e1dbc73c0bfc1088e7adfc9b5fd4a6f01a371fc2ecbeaba0dd0a2ed5f78e51a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aggression - physiology</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain - physiology</topic><topic>Cell Biology</topic><topic>Fighting</topic><topic>Gene Expression</topic><topic>Hypothalamus</topic><topic>Male</topic><topic>Mesencephalon</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Neostriatum</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Raphe nuclei</topic><topic>Ribonucleic acid</topic><topic>Ribosomal Proteins - biosynthesis</topic><topic>Ribosomal Proteins - genetics</topic><topic>RNA</topic><topic>Rodents</topic><topic>Sequence Analysis, RNA - methods</topic><topic>Ventral tegmentum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smagin, Dmitry A</creatorcontrib><creatorcontrib>Kovalenko, Irina L</creatorcontrib><creatorcontrib>Galyamina, Anna G</creatorcontrib><creatorcontrib>Orlov, Yuriy L</creatorcontrib><creatorcontrib>Babenko, Vladimir N</creatorcontrib><creatorcontrib>Kudryavtseva, Natalia N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smagin, Dmitry A</au><au>Kovalenko, Irina L</au><au>Galyamina, Anna G</au><au>Orlov, Yuriy L</au><au>Babenko, Vladimir N</au><au>Kudryavtseva, Natalia N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heterogeneity of Brain Ribosomal Genes Expression Following Positive Fighting Experience in Male Mice as Revealed by RNA-Seq</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>55</volume><issue>1</issue><spage>390</spage><epage>401</epage><pages>390-401</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Repeated positive fighting experience in daily agonistic interactions is accompanied by changes of brain neurotransmitter activity and genes’ expression in male mice. This paper is focused on the analysis of ribosomal genes expression data as revealed by whole-transcriptome analysis (RNA-Seq) in five brain regions of male mice with long repeated experience of aggression accompanied by wins (winners). Downregulation of most
Rps
,
Rpl
,
Mrps
, and
Mrpl
genes was found in the midbrain raphe nuclei and striatum and upregulation—in the hippocampus and hypothalamus of the winners. There were no changes in ribosomal gene expression in the ventral tegmental area. The data allow considering the alteration in ribosomal gene expression as an animal model of ribosomal dysfunction developed under positive fighting experience in male mice.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27957683</pmid><doi>10.1007/s12035-016-0327-z</doi><tpages>12</tpages></addata></record> |
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| ispartof | Molecular neurobiology, 2018-01, Vol.55 (1), p.390-401 |
| issn | 0893-7648 1559-1182 |
| language | eng |
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| source | Springer Nature |
| subjects | Aggression - physiology Animals Biomedical and Life Sciences Biomedicine Brain - physiology Cell Biology Fighting Gene Expression Hypothalamus Male Mesencephalon Mice Mice, Inbred C57BL Neostriatum Neurobiology Neurology Neurosciences Raphe nuclei Ribonucleic acid Ribosomal Proteins - biosynthesis Ribosomal Proteins - genetics RNA Rodents Sequence Analysis, RNA - methods Ventral tegmentum |
| title | Heterogeneity of Brain Ribosomal Genes Expression Following Positive Fighting Experience in Male Mice as Revealed by RNA-Seq |
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