Optimization of a DPI Inhaler: A Computational Approach

Alternate geometries of a commercial dry powder inhaler (DPI, i.e., Turbuhaler; AstraZeneca, London, UK) are proposed based on the simulation results obtained from a fluid and particle dynamic computational model, previously developed by Milenkovic et al. The alternate DPI geometries are constructed...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2017-03, Vol.106 (3), p.850-858
Main Authors: Milenkovic, Jovana, Alexopoulos, Aleck H., Kiparissides, Costas
Format: Article
Language:English
Subjects:
Administration, Inhalation
dispersion
Dry Powder Inhalers - instrumentation
Dry Powder Inhalers - standards
Equipment Design - instrumentation
Equipment Design - standards
mathematical model
microparticles
oral drug delivery
Particle Size
powder technology
simulations
Technology, Pharmaceutical - instrumentation
Technology, Pharmaceutical - standards
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Summary:Alternate geometries of a commercial dry powder inhaler (DPI, i.e., Turbuhaler; AstraZeneca, London, UK) are proposed based on the simulation results obtained from a fluid and particle dynamic computational model, previously developed by Milenkovic et al. The alternate DPI geometries are constructed by simple alterations to components of the commercial inhaler device leading to smoother flow patterns in regions where significant particle-wall collisions occur. The modified DPIs are investigated under the same conditions of the original studies of Milenkovic et al. for a wide range of inhalation flow rates (i.e., 30-70 L/min). Based on the computational results in terms of total particle deposition and fine particle fraction, the modified DPIs were improved over the original design of the commercial device.
ISSN:0022-3549
1520-6017
DOI:10.1016/j.xphs.2016.11.008