Undifferentiated connective tissue disease and interstitial lung disease: Trying to define patterns

OBJECTIVESTo identify clinical or immunological features in patients with undifferentiated connective tissue disease (UCTD) associated interstitial lung disease (ILD), in order to group them and recognize different functional and high resolution computed tomography (HRCT) behavior. METHODSRetrospect...

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Published in:Reumatología clinica (Barcelona) 2018-03, Vol.14 (2), p.75-80
Main Authors: Alberti, María Laura, Paulin, Francisco, Toledo, Heidegger Mateos, Fernández, Martín Eduardo, Caro, Fabián Matías, Rojas-Serrano, Jorge, Mejía, Mayra Edith
Format: Article
Language:eng ; spa
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Summary:OBJECTIVESTo identify clinical or immunological features in patients with undifferentiated connective tissue disease (UCTD) associated interstitial lung disease (ILD), in order to group them and recognize different functional and high resolution computed tomography (HRCT) behavior. METHODSRetrospective cohort study. Patients meeting Kinder criteria for UCTD were included. We defined the following predictive variables: 'highly specific' connective tissue disease (CTD) manifestations (Raynaud's phenomenon, dry eyes or arthritis), high antinuclear antibody (ANA) titer (above 1: 320), and 'specific' ANA staining patterns (centromere, cytoplasmic and nucleolar patterns). We evaluated the following outcomes: change in the percentage of the predicted forced vital capacity (FVC%) during the follow-up period, and HRCT pattern. RESULTSSixty-six patients were included. Twenty-nine (43.94%) showed at least one 'highly specific' CTD manifestation, 16 (28.57%) had a 'specific' ANA staining pattern and 29 (43.94%) high ANA titer. Patients with 'highly specific' CTD manifestations were younger (mean [SD] 52 years [14.58] vs 62.08 years [9.46], P
ISSN:2173-5743
DOI:10.1016/j.reuma.2016.10.007