Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides

An efficient and convenient palladium-catalyzed cyclization reaction of alkynes with isocyanides is described herein. This protocol allows the practical synthesis of many valuable polysubstituted maleimide derivatives after hydrolysis with a broad scope of substrates and mild reaction conditions. C–...

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Bibliographic Details
Published in:Journal of organic chemistry 2016-12, Vol.81 (24), p.12451-12458
Main Authors: Hu, Weigao, Zheng, Jia, Li, Jianxiao, Liu, Bifu, Wu, Wanqing, Liu, Haiyang, Jiang, Huanfeng
Format: Article
Language:English
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Summary:An efficient and convenient palladium-catalyzed cyclization reaction of alkynes with isocyanides is described herein. This protocol allows the practical synthesis of many valuable polysubstituted maleimide derivatives after hydrolysis with a broad scope of substrates and mild reaction conditions. C–C, CO, and C–N bonds were constructed in this transformation with isocyanide serving as both C and N sources.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.6b02227