Platelet-rich plasma: a biomimetic approach to enhancement of surgical wound healing

Abstract Platelets are small anucleate cytoplasmic cell bodies released by megakaryocytes in response to various physiologic triggers. Traditionally thought to be solely involved in the mechanisms of hemostasis, platelets have gained much attention due to their involvement wound healing, immunomodul...

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Bibliographic Details
Published in:The Journal of surgical research 2017-01, Vol.207, p.33-44
Main Authors: Fernandez-Moure, Joseph S., MD, MS, Van Eps, Jeffrey L., MD, Cabrera, Fernando J., MD, Barbosa, Zonia, MD, Medrano del Rosal, Guillermo, MD, Weiner, Bradley K., MD, Ellsworth, Warren A., MD, Tasciotti, Ennio, PhD
Format: Article
Language:English
Subjects:
Biomimetics
Blood Component Transfusion
Blood Platelets - physiology
Blood Transfusion, Autologous
Healing
Humans
Infection
Musculoskeletal
Neovascularization
Platelet-Rich Plasma
Surgery
Surgical Wound - physiopathology
Surgical Wound - therapy
Wound
Wound Healing - physiology
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Summary:Abstract Platelets are small anucleate cytoplasmic cell bodies released by megakaryocytes in response to various physiologic triggers. Traditionally thought to be solely involved in the mechanisms of hemostasis, platelets have gained much attention due to their involvement wound healing, immunomodulation, and antiseptic properties. As the field of surgery continues to evolve so does the need for therapies to aid in treating the increasingly complex patients seen. With over 14 million obstetric, musculoskeletal, and urological and gastrointestinal surgeries performed annually, the healing of surgical wounds continues to be of upmost importance to the surgeon and patient. Platelet-rich plasma, or platelet concentrate, has emerged as a possible adjuvant therapy to aid in the healing of surgical wounds and injuries. In this review, we will discuss the wound healing properties of platelet-rich plasma and various surgical applications.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2016.08.063