Radical Route to 1,4-Benzothiazine Derivatives from 2‑Aminobenzenethiols and Ketones under Transition-Metal-Free Conditions

Transition-metal-free radical access to 1,4-benzothiazine derivatives from o-aminobenzenethiols is disclosed. This procedure is available for various ketones including α,β-unsaturated, cyclic, linear, and fluoroalkyl ketones to generate a number of 1,4-benzothiazines, which exist in numerous bioacti...

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Published in:Organic letters 2016-12, Vol.18 (24), p.6424-6427
Main Authors: Lin, Ya-mei, Lu, Guo-ping, Wang, Rong-kang, Yi, Wen-bin
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Language:English
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creator Lin, Ya-mei
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description Transition-metal-free radical access to 1,4-benzothiazine derivatives from o-aminobenzenethiols is disclosed. This procedure is available for various ketones including α,β-unsaturated, cyclic, linear, and fluoroalkyl ketones to generate a number of 1,4-benzothiazines, which exist in numerous bioactive and natural molecules, rendering this protocol attractive to both synthetic and medicinal chemistry.
doi_str_mv 10.1021/acs.orglett.6b03324
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title Radical Route to 1,4-Benzothiazine Derivatives from 2‑Aminobenzenethiols and Ketones under Transition-Metal-Free Conditions
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