Left ventricular function in response to dipyridamole stress: head-to-head comparison between 82Rubidium PET and 99mTc-sestamibi SPECT ECG-gated myocardial perfusion imaging

• Published in: European journal of nuclear medicine and molecular imaging 2017-05, Vol.44 (5), p.876-885
• Main Authors: Giorgi, Maria Clementina, Meneghetti, Jose Claudio, Soares, Jose, Izaki, Marisa, Falcão, Andréa, Imada, Rodrigo, Chalela, William, de Oliveira, Marco Antonio, Nomura, Cesar, Verberne, Hein J.
• Format: Article
• Language: English
• Subjects: Cardiology; Imaging; Medicine; Medicine & Public Health; Nuclear Medicine; Oncology; Original Article; Orthopedics; Radiology
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-016-3588-x

Purpose Myocardial perfusion imaging (MPI) with 99m Tc-sestamibi (sestamibi) SPECT and rubidium-82 ( 82 Rb) PET both allow for combined assessment of perfusion and left ventricular (LV) function. We sought to compare parameters of LV function obtained with both methods using a single dipyridamole stress dose. Materials and methods A group of 221 consecutive patients (65.2 ± 10.4 years, 52.9% male) underwent consecutive sestamibi and 82 Rb MPI after a single dipyridamole stress dose. Sestamibi and 82 Rb summed rest (SRS), stress (SSS) and difference (SDS) scores, and LV end-diastolic (EDV) and end-systolic (ESV) volumes and left ventricular ejection fraction (LVEF) were compared. Results Bland-Altman analysis showed that with increasing ESV and EDV the difference between the two perfusion tracers increased both at rest and post-stress. The mean difference in EDV and ESV between the two perfusion tracers at rest could both be independently explained by the 82 Rb SDS and the sestamibi SRS. The combined models explained approximately 30% of the variation in these volumes between the two perfusion tracers (R 2  = 0.261, p  = 0.005; R 2  = 0.296, p