A clinical, histologic, and follow-up study of genital melanosis in men and women

Background Genital melanosis may clinically mimic melanoma. Little is known about the potential risk for genital and nongenital melanoma in these patients. Objective In this retrospective cohort study, we analyzed clinical and histologic data from patients with genital melanosis to better characteri...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2017-05, Vol.76 (5), p.836-840
Main Authors: Haugh, Alexandra M., BA, Merkel, Emily A., BA, Zhang, Bin, MS, Bubley, Jeffrey A., BA, Verzì, Anna Elisa, MD, Lee, Christina Y., BA, Gerami, Pedram, MD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Cell Count
Dermatology
Female
Follow-Up Studies
Genital Diseases, Female - pathology
Genital Diseases, Male - pathology
genital melanoma
genital melanosis
Humans
Male
Melanocytes - pathology
Melanoma - genetics
Melanoma - pathology
melanosis
Melanosis - pathology
Middle Aged
penile melanoma
Retrospective Studies
Risk Factors
Skin Neoplasms - genetics
Skin Neoplasms - pathology
Sox10
vulvar melanoma
Young Adult
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Summary:Background Genital melanosis may clinically mimic melanoma. Little is known about the potential risk for genital and nongenital melanoma in these patients. Objective In this retrospective cohort study, we analyzed clinical and histologic data from patients with genital melanosis to better characterize these lesions and the risk they confer for genital and nongenital melanoma. Methods In all, 41 patients were identified for a retrospective chart review and histologic analysis. Results Genital melanosis can clinically mimic melanoma but the typical age of onset is younger than for genital melanoma. A majority of lesions were found to stabilize or regress over time. Five patients were found to have a history of melanoma, only 1 of which was in the genital region. Lesions from these patients were more likely to show melanocytes with suprabasal movement ( P  = .0101) and to have a higher melanocyte count ( P  
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2016.11.003