Sarcopenia is a risk factor for cardiovascular events experienced by patients with critical limb ischemia

Abstract Background Prognosis is poor for patients with critical limb ischemia (CLI), and the most frequent cause of death is cardiovascular disease. Low grip strength is a risk factor for cardiovascular events, and sarcopenia may be associated as well. Thus, we hypothesized that sarcopenia is a ris...

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Bibliographic Details
Published in:Journal of vascular surgery 2017-05, Vol.65 (5), p.1390-1397
Main Authors: Matsubara, Yutaka, MD, Matsumoto, Takuya, MD, PhD, Inoue, Kentaro, MD, Matsuda, Daisuke, MD, Yoshiga, Ryosuke, MD, Yoshiya, Keiji, MD, Furuyama, Tadashi, MD, PhD, Maehara, Yoshihiko, MD, PhD
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cause of Death
Critical Illness
Cross-Sectional Studies
Disease-Free Survival
Female
Hand Strength
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Ischemia - complications
Ischemia - diagnosis
Ischemia - drug therapy
Ischemia - mortality
Kaplan-Meier Estimate
Male
Middle Aged
Muscle, Skeletal - diagnostic imaging
Muscle, Skeletal - physiopathology
Platelet Aggregation Inhibitors - therapeutic use
Proportional Hazards Models
Protective Factors
Retrospective Studies
Risk Assessment
Risk Factors
Sarcopenia - complications
Sarcopenia - diagnostic imaging
Sarcopenia - mortality
Sarcopenia - physiopathology
Surgery
Time Factors
Tomography, X-Ray Computed
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Summary:Abstract Background Prognosis is poor for patients with critical limb ischemia (CLI), and the most frequent cause of death is cardiovascular disease. Low grip strength is a risk factor for cardiovascular events, and sarcopenia may be associated as well. Thus, we hypothesized that sarcopenia is a risk factor for cardiovascular events experienced by patients with CLI. If this is true and appropriate therapy becomes available, the prognosis of patients with CLI will improve with appropriate risk management strategies to prevent cardiovascular events. Therefore, the aim of this study was to verify this hypothesis. Methods We studied 114 patients who underwent revascularization and computed tomography between January 2002 and December 2012 in the Department of Surgery and Sciences at Kyushu University in Japan. Sarcopenia was defined as skeletal muscle area measured by L3-level computed tomography scan 
ISSN:0741-5214
1097-6809
DOI:10.1016/j.jvs.2016.09.030