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Vitamin D metabolite concentrations in umbilical cord blood serum and associations with clinical characteristics in a large prospective mother-infant cohort in Ireland
•First CDC-accredited data for vitamin D metabolites in over 1000 umbilical cord blood samples.•46% of umbilical cord sera had 25(OH)D concentrations
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| Published in: | The Journal of steroid biochemistry and molecular biology 2017-03, Vol.167, p.162-168 |
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| container_title | The Journal of steroid biochemistry and molecular biology |
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| creator | Kiely, Mairead O’Donovan, Sinead M. Kenny, Louise C. Hourihane, Jonathan O’B. Irvine, Alan D. Murray, Deirdre M. |
| description | •First CDC-accredited data for vitamin D metabolites in over 1000 umbilical cord blood samples.•46% of umbilical cord sera had 25(OH)D concentrations |
| doi_str_mv | 10.1016/j.jsbmb.2016.12.006 |
| format | article |
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Vitamin D deficiency is widespread among mothers and neonates and quality clinical and analytical data are lacking. We used a CDC-accredited LC–MS/MS method to analyze vitamin D metabolites in cord sera from 1050 maternal-infant dyads in the prospective SCOPE Ireland Pregnancy and BASELINE Birth cohort studies, based in Cork, Ireland. The mean±SD total 25(OH)D was 34.9±18.1nmol/L; 35% of cords (50% during winter) had 25(OH)D <25nmol/L, 46% were <30nmol/L and 80% were <50nmol/L. In this predominantly white cohort, the main predictor of cord 25(OH)D [adj. mean difference in nmol/L (95% CI)] was summer delivery [19.2 (17.4, 20.9), P<0.0001]. Maternal smoking during pregnancy (9% prevalence) was negatively associated (P<0.002) with cord 25(OH)D [−4.83 (−7.9, −1.5) nmol/L]. There were no associations between cord 25(OH)D and birth weight or any anthropometric measures at birth. Despite the high prevalence of vitamin D deficiency at birth, there were no documented musculoskeletal complications during infancy, which was likely due to widespread supplementation with vitamin D. The mean±SD concentration of 3-epi-25(OH)D3, detectable in 99.4% of cord samples, was 3.3±1.9nmol/L. The proportion of 25(OH)D as 3-epi-25(OH)D3 was 11.2%. Cord 3-epi-25(OH)D3 concentrations were positively predicted by cord 25(OH)D3 [0.101 (0.099, 0.103) nmol/L, P<0.0001] and negatively by gestational age [−0.104 (−0.131, −0.076) nmol/L, P<0.0001] and maternal age [−0.010 (−0.019, −0.001) nmol/L, P<0.05]. 25(OH)D2 was detected in 98% of cord sera (mean±SD; 2.2±1.9nmol/L) despite low antenatal consumption of vitamin D2 supplements. In conclusion, these first CDC-accredited data of vitamin D metabolites in umbilical cord blood emphasise the high risk of very low vitamin D status in infants born to un-supplemented mothers. Experimental data to define maternal vitamin D requirements for prevention of neonatal deficiency at high latitude are required.]]></description><identifier>ISSN: 0960-0760</identifier><identifier>EISSN: 1879-1220</identifier><identifier>DOI: 10.1016/j.jsbmb.2016.12.006</identifier><identifier>PMID: 28007533</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>25-Hydroxyvitamin D ; 3-epi-25-hydroxyvitamin D ; Adult ; Anthropometry ; birth cohort ; Birth weight ; Chromatography, Liquid ; Cohort Studies ; Cord blood ; Data processing ; Female ; Fetal Blood - chemistry ; Gestational Age ; Humans ; Infant, Newborn ; Infants ; Ireland ; Longitudinal Studies ; Male ; Maternal Age ; Metabolites ; Neonates ; Pregnancy ; Pregnancy complications ; Prospective Studies ; Seasons ; Serum - chemistry ; Smoking ; Smoking - adverse effects ; Studies ; Supplements ; Tandem Mass Spectrometry ; Umbilical cord ; Umbilical Cord - chemistry ; umbilical cord blood ; Vitamin D ; Vitamin D - blood ; Vitamin D - metabolism ; Vitamin D deficiency ; Vitamin D Deficiency - blood ; Vitamin D2 ; Vitamin deficiency</subject><ispartof>The Journal of steroid biochemistry and molecular biology, 2017-03, Vol.167, p.162-168</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Mar 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-4321d14393a4da25a600c4c7635e9c12918db9ae5c55ba2f10bccc0f7e7895243</citedby><cites>FETCH-LOGICAL-c387t-4321d14393a4da25a600c4c7635e9c12918db9ae5c55ba2f10bccc0f7e7895243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28007533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiely, Mairead</creatorcontrib><creatorcontrib>O’Donovan, Sinead M.</creatorcontrib><creatorcontrib>Kenny, Louise C.</creatorcontrib><creatorcontrib>Hourihane, Jonathan O’B.</creatorcontrib><creatorcontrib>Irvine, Alan D.</creatorcontrib><creatorcontrib>Murray, Deirdre M.</creatorcontrib><title>Vitamin D metabolite concentrations in umbilical cord blood serum and associations with clinical characteristics in a large prospective mother-infant cohort in Ireland</title><title>The Journal of steroid biochemistry and molecular biology</title><addtitle>J Steroid Biochem Mol Biol</addtitle><description><![CDATA[•First CDC-accredited data for vitamin D metabolites in over 1000 umbilical cord blood samples.•46% of umbilical cord sera had 25(OH)D concentrations <30nmol/L and 80% were <50nmol/L.•Maternal smoking during pregnancy was a negative predictor of cord 25(OH)D [−4.83 (−7.9, −1.5) nmol/L].•Cord 25(OH)D was not associated with birth weight or any anthropometric measures at birth.•Cord 3-epi-25(OH)D3 was negatively associated with gestational age and maternal age.
Vitamin D deficiency is widespread among mothers and neonates and quality clinical and analytical data are lacking. We used a CDC-accredited LC–MS/MS method to analyze vitamin D metabolites in cord sera from 1050 maternal-infant dyads in the prospective SCOPE Ireland Pregnancy and BASELINE Birth cohort studies, based in Cork, Ireland. The mean±SD total 25(OH)D was 34.9±18.1nmol/L; 35% of cords (50% during winter) had 25(OH)D <25nmol/L, 46% were <30nmol/L and 80% were <50nmol/L. In this predominantly white cohort, the main predictor of cord 25(OH)D [adj. mean difference in nmol/L (95% CI)] was summer delivery [19.2 (17.4, 20.9), P<0.0001]. Maternal smoking during pregnancy (9% prevalence) was negatively associated (P<0.002) with cord 25(OH)D [−4.83 (−7.9, −1.5) nmol/L]. There were no associations between cord 25(OH)D and birth weight or any anthropometric measures at birth. Despite the high prevalence of vitamin D deficiency at birth, there were no documented musculoskeletal complications during infancy, which was likely due to widespread supplementation with vitamin D. The mean±SD concentration of 3-epi-25(OH)D3, detectable in 99.4% of cord samples, was 3.3±1.9nmol/L. The proportion of 25(OH)D as 3-epi-25(OH)D3 was 11.2%. Cord 3-epi-25(OH)D3 concentrations were positively predicted by cord 25(OH)D3 [0.101 (0.099, 0.103) nmol/L, P<0.0001] and negatively by gestational age [−0.104 (−0.131, −0.076) nmol/L, P<0.0001] and maternal age [−0.010 (−0.019, −0.001) nmol/L, P<0.05]. 25(OH)D2 was detected in 98% of cord sera (mean±SD; 2.2±1.9nmol/L) despite low antenatal consumption of vitamin D2 supplements. In conclusion, these first CDC-accredited data of vitamin D metabolites in umbilical cord blood emphasise the high risk of very low vitamin D status in infants born to un-supplemented mothers. Experimental data to define maternal vitamin D requirements for prevention of neonatal deficiency at high latitude are required.]]></description><subject>25-Hydroxyvitamin D</subject><subject>3-epi-25-hydroxyvitamin D</subject><subject>Adult</subject><subject>Anthropometry</subject><subject>birth cohort</subject><subject>Birth weight</subject><subject>Chromatography, Liquid</subject><subject>Cohort Studies</subject><subject>Cord blood</subject><subject>Data processing</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Ireland</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Maternal Age</subject><subject>Metabolites</subject><subject>Neonates</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Prospective Studies</subject><subject>Seasons</subject><subject>Serum - chemistry</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Studies</subject><subject>Supplements</subject><subject>Tandem Mass Spectrometry</subject><subject>Umbilical cord</subject><subject>Umbilical Cord - chemistry</subject><subject>umbilical cord blood</subject><subject>Vitamin D</subject><subject>Vitamin D - blood</subject><subject>Vitamin D - metabolism</subject><subject>Vitamin D deficiency</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D2</subject><subject>Vitamin deficiency</subject><issn>0960-0760</issn><issn>1879-1220</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kb-O1DAQxi0E4paDJ0BClmhoEsZ2EscFBbrjz0kn0QCt5TgT1pETL7ZziCfiNfHeLhQUVJY1v_nmm_kIec6gZsC613M9p2EZal4-NeM1QPeA7FgvVcU4h4dkB6qDCmQHF-RJSjMACMHkY3LBewDZCrEjv766bBa30mu6YDZD8C4jtWG1uOZosgtroqW8LYPzzhpfanGkgw9hpAnjtlCzjtSkFKw74z9c3lPr3Xri9yYamzG6lJ29FzPUm_gN6SGGdECb3R3SJeQ9xsqtk1lzGbIPMR_Zm4i-THhKHk3GJ3x2fi_Jl_fvPl99rG4_fbi5entbWdHLXDWCs5E1QgnTjIa3pgOwjZWdaFFZxhXrx0EZbG3bDoZPDAZrLUwSZa9a3ohL8uqkW7x93zBlvbhk0RcPGLakWd9y2fOei4K-_AedwxbX4k4zJZVqGXRHQXGibFk2RZz0IbrFxJ-agT7mqGd9n6M-5qgZ1yXH0vXirL0NC45_e_4EV4A3JwDLMe4cRp2sw5La6GK5qB6D---A369ysqs</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Kiely, Mairead</creator><creator>O’Donovan, Sinead M.</creator><creator>Kenny, Louise C.</creator><creator>Hourihane, Jonathan O’B.</creator><creator>Irvine, Alan D.</creator><creator>Murray, Deirdre M.</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201703</creationdate><title>Vitamin D metabolite concentrations in umbilical cord blood serum and associations with clinical characteristics in a large prospective mother-infant cohort in Ireland</title><author>Kiely, Mairead ; O’Donovan, Sinead M. ; Kenny, Louise C. ; Hourihane, Jonathan O’B. ; Irvine, Alan D. ; Murray, Deirdre M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-4321d14393a4da25a600c4c7635e9c12918db9ae5c55ba2f10bccc0f7e7895243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>25-Hydroxyvitamin D</topic><topic>3-epi-25-hydroxyvitamin D</topic><topic>Adult</topic><topic>Anthropometry</topic><topic>birth cohort</topic><topic>Birth weight</topic><topic>Chromatography, Liquid</topic><topic>Cohort Studies</topic><topic>Cord blood</topic><topic>Data processing</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Ireland</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Maternal Age</topic><topic>Metabolites</topic><topic>Neonates</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Prospective Studies</topic><topic>Seasons</topic><topic>Serum - chemistry</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Studies</topic><topic>Supplements</topic><topic>Tandem Mass Spectrometry</topic><topic>Umbilical cord</topic><topic>Umbilical Cord - chemistry</topic><topic>umbilical cord blood</topic><topic>Vitamin D</topic><topic>Vitamin D - blood</topic><topic>Vitamin D - metabolism</topic><topic>Vitamin D deficiency</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D2</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiely, Mairead</creatorcontrib><creatorcontrib>O’Donovan, Sinead M.</creatorcontrib><creatorcontrib>Kenny, Louise C.</creatorcontrib><creatorcontrib>Hourihane, Jonathan O’B.</creatorcontrib><creatorcontrib>Irvine, Alan D.</creatorcontrib><creatorcontrib>Murray, Deirdre M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiely, Mairead</au><au>O’Donovan, Sinead M.</au><au>Kenny, Louise C.</au><au>Hourihane, Jonathan O’B.</au><au>Irvine, Alan D.</au><au>Murray, Deirdre M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D metabolite concentrations in umbilical cord blood serum and associations with clinical characteristics in a large prospective mother-infant cohort in Ireland</atitle><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle><addtitle>J Steroid Biochem Mol Biol</addtitle><date>2017-03</date><risdate>2017</risdate><volume>167</volume><spage>162</spage><epage>168</epage><pages>162-168</pages><issn>0960-0760</issn><eissn>1879-1220</eissn><abstract><![CDATA[•First CDC-accredited data for vitamin D metabolites in over 1000 umbilical cord blood samples.•46% of umbilical cord sera had 25(OH)D concentrations <30nmol/L and 80% were <50nmol/L.•Maternal smoking during pregnancy was a negative predictor of cord 25(OH)D [−4.83 (−7.9, −1.5) nmol/L].•Cord 25(OH)D was not associated with birth weight or any anthropometric measures at birth.•Cord 3-epi-25(OH)D3 was negatively associated with gestational age and maternal age.
Vitamin D deficiency is widespread among mothers and neonates and quality clinical and analytical data are lacking. We used a CDC-accredited LC–MS/MS method to analyze vitamin D metabolites in cord sera from 1050 maternal-infant dyads in the prospective SCOPE Ireland Pregnancy and BASELINE Birth cohort studies, based in Cork, Ireland. The mean±SD total 25(OH)D was 34.9±18.1nmol/L; 35% of cords (50% during winter) had 25(OH)D <25nmol/L, 46% were <30nmol/L and 80% were <50nmol/L. In this predominantly white cohort, the main predictor of cord 25(OH)D [adj. mean difference in nmol/L (95% CI)] was summer delivery [19.2 (17.4, 20.9), P<0.0001]. Maternal smoking during pregnancy (9% prevalence) was negatively associated (P<0.002) with cord 25(OH)D [−4.83 (−7.9, −1.5) nmol/L]. There were no associations between cord 25(OH)D and birth weight or any anthropometric measures at birth. Despite the high prevalence of vitamin D deficiency at birth, there were no documented musculoskeletal complications during infancy, which was likely due to widespread supplementation with vitamin D. The mean±SD concentration of 3-epi-25(OH)D3, detectable in 99.4% of cord samples, was 3.3±1.9nmol/L. The proportion of 25(OH)D as 3-epi-25(OH)D3 was 11.2%. Cord 3-epi-25(OH)D3 concentrations were positively predicted by cord 25(OH)D3 [0.101 (0.099, 0.103) nmol/L, P<0.0001] and negatively by gestational age [−0.104 (−0.131, −0.076) nmol/L, P<0.0001] and maternal age [−0.010 (−0.019, −0.001) nmol/L, P<0.05]. 25(OH)D2 was detected in 98% of cord sera (mean±SD; 2.2±1.9nmol/L) despite low antenatal consumption of vitamin D2 supplements. In conclusion, these first CDC-accredited data of vitamin D metabolites in umbilical cord blood emphasise the high risk of very low vitamin D status in infants born to un-supplemented mothers. Experimental data to define maternal vitamin D requirements for prevention of neonatal deficiency at high latitude are required.]]></abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28007533</pmid><doi>10.1016/j.jsbmb.2016.12.006</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of steroid biochemistry and molecular biology, 2017-03, Vol.167, p.162-168 |
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| subjects | 25-Hydroxyvitamin D 3-epi-25-hydroxyvitamin D Adult Anthropometry birth cohort Birth weight Chromatography, Liquid Cohort Studies Cord blood Data processing Female Fetal Blood - chemistry Gestational Age Humans Infant, Newborn Infants Ireland Longitudinal Studies Male Maternal Age Metabolites Neonates Pregnancy Pregnancy complications Prospective Studies Seasons Serum - chemistry Smoking Smoking - adverse effects Studies Supplements Tandem Mass Spectrometry Umbilical cord Umbilical Cord - chemistry umbilical cord blood Vitamin D Vitamin D - blood Vitamin D - metabolism Vitamin D deficiency Vitamin D Deficiency - blood Vitamin D2 Vitamin deficiency |
| title | Vitamin D metabolite concentrations in umbilical cord blood serum and associations with clinical characteristics in a large prospective mother-infant cohort in Ireland |
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