Loading…
Adherence to medication and characteristics of Japanese patients with non-valvular atrial fibrillation
Abstract Background Adherence to medication plays an important role in the prevention of morbidity and mortality in non-valvular atrial fibrillation (NVAF) patients. The aim of this study is to assess adherence to medication and risk factors for non-adherence in Japanese NVAF patients who are prescr...
Saved in:
| Published in: | Journal of cardiology 2017-09, Vol.70 (3), p.238-243 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c479t-69e36b2abfa4abd33aeeed166f73d2c18b6729da4e34c6c0473c7e1b5ea8a4aa3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c479t-69e36b2abfa4abd33aeeed166f73d2c18b6729da4e34c6c0473c7e1b5ea8a4aa3 |
| container_end_page | 243 |
| container_issue | 3 |
| container_start_page | 238 |
| container_title | Journal of cardiology |
| container_volume | 70 |
| creator | Suzuki, Tsuyoshi, MD Shiga, Tsuyoshi, MD, FJCC Omori, Hisako, MD Tatsumi, Fujio, MD Nishimura, Katsuji, MD Hagiwara, Nobuhisa, MD, FJCC |
| description | Abstract Background Adherence to medication plays an important role in the prevention of morbidity and mortality in non-valvular atrial fibrillation (NVAF) patients. The aim of this study is to assess adherence to medication and risk factors for non-adherence in Japanese NVAF patients who are prescribed anticoagulants. Methods A total of 378 outpatients with NVAF who completed self-reported questionnaires were analyzed in this prospective study (mean age 69 ± 12 years; 26% female). Self-reported adherence to cardiovascular drugs including anticoagulants was measured with a modified Siegal scale. Depression was defined as a Patient Health Questionnaire-9 score of ≥10. Univariate and multivariate analyses were performed on several variables to analyze factors affecting non-adherence. Results In total, 291 (77%) of our patients received warfarin, and the remainder received direct oral anticoagulants. Fifty-two (14%) patients were defined as non-adherent. Univariate analyses showed that age |
| doi_str_mv | 10.1016/j.jjcc.2016.11.009 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1852782949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0914508716303070</els_id><sourcerecordid>1852782949</sourcerecordid><originalsourceid>FETCH-LOGICAL-c479t-69e36b2abfa4abd33aeeed166f73d2c18b6729da4e34c6c0473c7e1b5ea8a4aa3</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS0EotvCF-CAfOSS4D9ZO5EQUlXRAqrUQ-FsTeyJ1iHrLLazqN8ep1s4cOA0c3jvaeb3CHnDWc0ZV-_HehytrUXZa85rxrpnZMNbrapGy_Y52bCON9WWtfqMnKc0MqZY16qX5Ey0jOmGiw0ZLt0OIwaLNM90j85byH4OFIKjdgcRbMboU_Y20XmgX-EAARPSQ5FhyIn-8nlHwxyqI0zHZYJIIUcPEx18H_00Pca9Ii8GmBK-fpoX5Pv1p29Xn6vbu5svV5e3lW10lyvVoVS9gH6ABnonJSCi40oNWjphedsrLToHDcrGKsvKn1Yj77cIbXGAvCDvTrmHOP9cMGWz98liuSLgvCTD263QreiarkjFSWrjnFLEwRyi30N8MJyZla8ZzcrXrHwN56bwLaa3T_lLX2D9tfwBWgQfTgIsXx49RpOsX_E6H9Fm42b___yP_9jt5EPpZPqBD5jGeYmh8DPcJGGYuV8bXgvmSjLJNJO_AVR6o20</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1852782949</pqid></control><display><type>article</type><title>Adherence to medication and characteristics of Japanese patients with non-valvular atrial fibrillation</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Suzuki, Tsuyoshi, MD ; Shiga, Tsuyoshi, MD, FJCC ; Omori, Hisako, MD ; Tatsumi, Fujio, MD ; Nishimura, Katsuji, MD ; Hagiwara, Nobuhisa, MD, FJCC</creator><creatorcontrib>Suzuki, Tsuyoshi, MD ; Shiga, Tsuyoshi, MD, FJCC ; Omori, Hisako, MD ; Tatsumi, Fujio, MD ; Nishimura, Katsuji, MD ; Hagiwara, Nobuhisa, MD, FJCC</creatorcontrib><description>Abstract Background Adherence to medication plays an important role in the prevention of morbidity and mortality in non-valvular atrial fibrillation (NVAF) patients. The aim of this study is to assess adherence to medication and risk factors for non-adherence in Japanese NVAF patients who are prescribed anticoagulants. Methods A total of 378 outpatients with NVAF who completed self-reported questionnaires were analyzed in this prospective study (mean age 69 ± 12 years; 26% female). Self-reported adherence to cardiovascular drugs including anticoagulants was measured with a modified Siegal scale. Depression was defined as a Patient Health Questionnaire-9 score of ≥10. Univariate and multivariate analyses were performed on several variables to analyze factors affecting non-adherence. Results In total, 291 (77%) of our patients received warfarin, and the remainder received direct oral anticoagulants. Fifty-two (14%) patients were defined as non-adherent. Univariate analyses showed that age <65 years, ≥2 times daily dosing of cardiovascular drugs and employment, but not depression, were significantly associated with non-adherence, 1.87 (95% CI: 1.01–3.42, p = 0.04), 2.97 (95% CI: 1.64–5.49, p < 0.01), 2.11 (95% CI: 1.16–3.93, p = 0.01), and 0.74 (95% CI: 0.26–2.64), respectively. Multivariate analysis showed that only ≥2 times daily dosing was a significant independent risk factor (HR 3.06, 95% CI: 1.67–5.69, p < 0.01). Conclusions Our study showed that the prevalence of non-adherence to medications was 14% in NVAF patients. Frequent daily dosing was an independent risk factor for non-adherence to medication (UMIN-CTR No. UMIN 000023514).</description><identifier>ISSN: 0914-5087</identifier><identifier>EISSN: 1876-4738</identifier><identifier>DOI: 10.1016/j.jjcc.2016.11.009</identifier><identifier>PMID: 28007412</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adherence ; Aged ; Aged, 80 and over ; Anticoagulants ; Anticoagulants - administration & dosage ; Anticoagulants - therapeutic use ; Asian Continental Ancestry Group ; Atrial fibrillation ; Atrial Fibrillation - drug therapy ; Atrial Fibrillation - psychology ; Cardiovascular ; Depression - drug therapy ; Depression - psychology ; Drug Administration Schedule ; Female ; Humans ; Japanese ; Male ; Medication Adherence - psychology ; Medication Adherence - statistics & numerical data ; Middle Aged ; Risk Factors ; Warfarin - administration & dosage ; Warfarin - therapeutic use</subject><ispartof>Journal of cardiology, 2017-09, Vol.70 (3), p.238-243</ispartof><rights>Japanese College of Cardiology</rights><rights>2016 Japanese College of Cardiology</rights><rights>Copyright © 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-69e36b2abfa4abd33aeeed166f73d2c18b6729da4e34c6c0473c7e1b5ea8a4aa3</citedby><cites>FETCH-LOGICAL-c479t-69e36b2abfa4abd33aeeed166f73d2c18b6729da4e34c6c0473c7e1b5ea8a4aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28007412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Tsuyoshi, MD</creatorcontrib><creatorcontrib>Shiga, Tsuyoshi, MD, FJCC</creatorcontrib><creatorcontrib>Omori, Hisako, MD</creatorcontrib><creatorcontrib>Tatsumi, Fujio, MD</creatorcontrib><creatorcontrib>Nishimura, Katsuji, MD</creatorcontrib><creatorcontrib>Hagiwara, Nobuhisa, MD, FJCC</creatorcontrib><title>Adherence to medication and characteristics of Japanese patients with non-valvular atrial fibrillation</title><title>Journal of cardiology</title><addtitle>J Cardiol</addtitle><description>Abstract Background Adherence to medication plays an important role in the prevention of morbidity and mortality in non-valvular atrial fibrillation (NVAF) patients. The aim of this study is to assess adherence to medication and risk factors for non-adherence in Japanese NVAF patients who are prescribed anticoagulants. Methods A total of 378 outpatients with NVAF who completed self-reported questionnaires were analyzed in this prospective study (mean age 69 ± 12 years; 26% female). Self-reported adherence to cardiovascular drugs including anticoagulants was measured with a modified Siegal scale. Depression was defined as a Patient Health Questionnaire-9 score of ≥10. Univariate and multivariate analyses were performed on several variables to analyze factors affecting non-adherence. Results In total, 291 (77%) of our patients received warfarin, and the remainder received direct oral anticoagulants. Fifty-two (14%) patients were defined as non-adherent. Univariate analyses showed that age <65 years, ≥2 times daily dosing of cardiovascular drugs and employment, but not depression, were significantly associated with non-adherence, 1.87 (95% CI: 1.01–3.42, p = 0.04), 2.97 (95% CI: 1.64–5.49, p < 0.01), 2.11 (95% CI: 1.16–3.93, p = 0.01), and 0.74 (95% CI: 0.26–2.64), respectively. Multivariate analysis showed that only ≥2 times daily dosing was a significant independent risk factor (HR 3.06, 95% CI: 1.67–5.69, p < 0.01). Conclusions Our study showed that the prevalence of non-adherence to medications was 14% in NVAF patients. Frequent daily dosing was an independent risk factor for non-adherence to medication (UMIN-CTR No. UMIN 000023514).</description><subject>Adherence</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anticoagulants</subject><subject>Anticoagulants - administration & dosage</subject><subject>Anticoagulants - therapeutic use</subject><subject>Asian Continental Ancestry Group</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - drug therapy</subject><subject>Atrial Fibrillation - psychology</subject><subject>Cardiovascular</subject><subject>Depression - drug therapy</subject><subject>Depression - psychology</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Humans</subject><subject>Japanese</subject><subject>Male</subject><subject>Medication Adherence - psychology</subject><subject>Medication Adherence - statistics & numerical data</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Warfarin - administration & dosage</subject><subject>Warfarin - therapeutic use</subject><issn>0914-5087</issn><issn>1876-4738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kU9v1DAQxS0EotvCF-CAfOSS4D9ZO5EQUlXRAqrUQ-FsTeyJ1iHrLLazqN8ep1s4cOA0c3jvaeb3CHnDWc0ZV-_HehytrUXZa85rxrpnZMNbrapGy_Y52bCON9WWtfqMnKc0MqZY16qX5Ey0jOmGiw0ZLt0OIwaLNM90j85byH4OFIKjdgcRbMboU_Y20XmgX-EAARPSQ5FhyIn-8nlHwxyqI0zHZYJIIUcPEx18H_00Pca9Ii8GmBK-fpoX5Pv1p29Xn6vbu5svV5e3lW10lyvVoVS9gH6ABnonJSCi40oNWjphedsrLToHDcrGKsvKn1Yj77cIbXGAvCDvTrmHOP9cMGWz98liuSLgvCTD263QreiarkjFSWrjnFLEwRyi30N8MJyZla8ZzcrXrHwN56bwLaa3T_lLX2D9tfwBWgQfTgIsXx49RpOsX_E6H9Fm42b___yP_9jt5EPpZPqBD5jGeYmh8DPcJGGYuV8bXgvmSjLJNJO_AVR6o20</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Suzuki, Tsuyoshi, MD</creator><creator>Shiga, Tsuyoshi, MD, FJCC</creator><creator>Omori, Hisako, MD</creator><creator>Tatsumi, Fujio, MD</creator><creator>Nishimura, Katsuji, MD</creator><creator>Hagiwara, Nobuhisa, MD, FJCC</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170901</creationdate><title>Adherence to medication and characteristics of Japanese patients with non-valvular atrial fibrillation</title><author>Suzuki, Tsuyoshi, MD ; Shiga, Tsuyoshi, MD, FJCC ; Omori, Hisako, MD ; Tatsumi, Fujio, MD ; Nishimura, Katsuji, MD ; Hagiwara, Nobuhisa, MD, FJCC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-69e36b2abfa4abd33aeeed166f73d2c18b6729da4e34c6c0473c7e1b5ea8a4aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adherence</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anticoagulants</topic><topic>Anticoagulants - administration & dosage</topic><topic>Anticoagulants - therapeutic use</topic><topic>Asian Continental Ancestry Group</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - drug therapy</topic><topic>Atrial Fibrillation - psychology</topic><topic>Cardiovascular</topic><topic>Depression - drug therapy</topic><topic>Depression - psychology</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Humans</topic><topic>Japanese</topic><topic>Male</topic><topic>Medication Adherence - psychology</topic><topic>Medication Adherence - statistics & numerical data</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Warfarin - administration & dosage</topic><topic>Warfarin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Tsuyoshi, MD</creatorcontrib><creatorcontrib>Shiga, Tsuyoshi, MD, FJCC</creatorcontrib><creatorcontrib>Omori, Hisako, MD</creatorcontrib><creatorcontrib>Tatsumi, Fujio, MD</creatorcontrib><creatorcontrib>Nishimura, Katsuji, MD</creatorcontrib><creatorcontrib>Hagiwara, Nobuhisa, MD, FJCC</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Tsuyoshi, MD</au><au>Shiga, Tsuyoshi, MD, FJCC</au><au>Omori, Hisako, MD</au><au>Tatsumi, Fujio, MD</au><au>Nishimura, Katsuji, MD</au><au>Hagiwara, Nobuhisa, MD, FJCC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adherence to medication and characteristics of Japanese patients with non-valvular atrial fibrillation</atitle><jtitle>Journal of cardiology</jtitle><addtitle>J Cardiol</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>70</volume><issue>3</issue><spage>238</spage><epage>243</epage><pages>238-243</pages><issn>0914-5087</issn><eissn>1876-4738</eissn><abstract>Abstract Background Adherence to medication plays an important role in the prevention of morbidity and mortality in non-valvular atrial fibrillation (NVAF) patients. The aim of this study is to assess adherence to medication and risk factors for non-adherence in Japanese NVAF patients who are prescribed anticoagulants. Methods A total of 378 outpatients with NVAF who completed self-reported questionnaires were analyzed in this prospective study (mean age 69 ± 12 years; 26% female). Self-reported adherence to cardiovascular drugs including anticoagulants was measured with a modified Siegal scale. Depression was defined as a Patient Health Questionnaire-9 score of ≥10. Univariate and multivariate analyses were performed on several variables to analyze factors affecting non-adherence. Results In total, 291 (77%) of our patients received warfarin, and the remainder received direct oral anticoagulants. Fifty-two (14%) patients were defined as non-adherent. Univariate analyses showed that age <65 years, ≥2 times daily dosing of cardiovascular drugs and employment, but not depression, were significantly associated with non-adherence, 1.87 (95% CI: 1.01–3.42, p = 0.04), 2.97 (95% CI: 1.64–5.49, p < 0.01), 2.11 (95% CI: 1.16–3.93, p = 0.01), and 0.74 (95% CI: 0.26–2.64), respectively. Multivariate analysis showed that only ≥2 times daily dosing was a significant independent risk factor (HR 3.06, 95% CI: 1.67–5.69, p < 0.01). Conclusions Our study showed that the prevalence of non-adherence to medications was 14% in NVAF patients. Frequent daily dosing was an independent risk factor for non-adherence to medication (UMIN-CTR No. UMIN 000023514).</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>28007412</pmid><doi>10.1016/j.jjcc.2016.11.009</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0914-5087 |
| ispartof | Journal of cardiology, 2017-09, Vol.70 (3), p.238-243 |
| issn | 0914-5087 1876-4738 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1852782949 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adherence Aged Aged, 80 and over Anticoagulants Anticoagulants - administration & dosage Anticoagulants - therapeutic use Asian Continental Ancestry Group Atrial fibrillation Atrial Fibrillation - drug therapy Atrial Fibrillation - psychology Cardiovascular Depression - drug therapy Depression - psychology Drug Administration Schedule Female Humans Japanese Male Medication Adherence - psychology Medication Adherence - statistics & numerical data Middle Aged Risk Factors Warfarin - administration & dosage Warfarin - therapeutic use |
| title | Adherence to medication and characteristics of Japanese patients with non-valvular atrial fibrillation |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T12%3A26%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adherence%20to%20medication%20and%20characteristics%20of%20Japanese%20patients%20with%20non-valvular%20atrial%20fibrillation&rft.jtitle=Journal%20of%20cardiology&rft.au=Suzuki,%20Tsuyoshi,%20MD&rft.date=2017-09-01&rft.volume=70&rft.issue=3&rft.spage=238&rft.epage=243&rft.pages=238-243&rft.issn=0914-5087&rft.eissn=1876-4738&rft_id=info:doi/10.1016/j.jjcc.2016.11.009&rft_dat=%3Cproquest_cross%3E1852782949%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c479t-69e36b2abfa4abd33aeeed166f73d2c18b6729da4e34c6c0473c7e1b5ea8a4aa3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1852782949&rft_id=info:pmid/28007412&rfr_iscdi=true |