HURTLE CELLS IMMUNOHISTOCHEMICAL ACTIVITIES IN HASHIMOTO THYROIDITIS PARENCHYMA

The present study was designed to evaluate the participation and utility of Hǘrtle cells morphological requirment and transformation under Hashimoto autoimmune thyroiditis versus Riedel´s struma. Several markers have been evaluated to detect induced activities of Hǘrtle cells. Study subject - specim...

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Bibliographic Details
Published in:Georgian medical news 2016-11 (Issue), p.42-46
Main Authors: Tsagareli, Z, Kvachadze, T, Melikadze, E, Metreveli, L, Nikobadze, E, Gogiashvili, L
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - blood
Autoantigens - immunology
Female
Fibrosis
Hashimoto Disease - metabolism
Hashimoto Disease - pathology
Humans
Iodide Peroxidase - immunology
Iron-Binding Proteins - immunology
Male
Middle Aged
Nuclear Proteins - metabolism
Oxyphil Cells - metabolism
Parenchymal Tissue - metabolism
Parenchymal Tissue - pathology
Receptors, Thyrotropin - metabolism
S100 Proteins - metabolism
Thyroid Gland - metabolism
Thyroid Gland - pathology
Thyroid Nuclear Factor 1
Transcription Factors - metabolism
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Summary:The present study was designed to evaluate the participation and utility of Hǘrtle cells morphological requirment and transformation under Hashimoto autoimmune thyroiditis versus Riedel´s struma. Several markers have been evaluated to detect induced activities of Hǘrtle cells. Study subject - specimens (tissue fragments) collected from TG surgery (thyroidectomy) for mollecular (receptor) diagnosis of Hǘrtle cells activities using routine histological and immunohistochemical samples. 89 cases were selected in Hashimoto thyroiditis diagnosis with Hǘrtle cells history (adenoma and adenomatous grouth of oncocytes). Markers as: TSH receptors, TTF-1, S-100 protein, also anti-TPO and anti-TG levels in blood plasm were detected. It was shown that solid cell claster-nests like agregation of oncocytes and adenomatous growth foci in parafollicular areas with anti-TPO and anti-TG antibodies levels arising while Riedel´s struma shown only large intra- and extra glandular inflammatory proliferative fibrosing process. Large positive expression of TTF-1 and S-100 protein and the negative reaction of TSH receptor factor suggest that Thyroid parenchyma disorganization and mollecular biological atypia with Hǘrtle cells are proceses due to hypothyreoidismus, as well as neuroectodermal cells prominent activities in 70% of Hashimoto cases.
ISSN:1512-0112