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Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric Cancer
The clinicopathological significance of oncofetal mRNA-binding protein, human insulin-like growth factor II mRNA-binding protein 3 (IMP3), in gastric carcinoma (GC) is not fully understood. Tissue microarray blocks with specimens from 346 patients with GC were constructed to evaluate the clinicopath...
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| Published in: | Anticancer research 2017-01, Vol.37 (1), p.135-142 |
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| container_end_page | 142 |
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| container_start_page | 135 |
| container_title | Anticancer research |
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| creator | Lee, Dakeun Yu, Eun Ji Ham, In-Hye Hur, Hoon |
| description | The clinicopathological significance of oncofetal mRNA-binding protein, human insulin-like growth factor II mRNA-binding protein 3 (IMP3), in gastric carcinoma (GC) is not fully understood.
Tissue microarray blocks with specimens from 346 patients with GC were constructed to evaluate the clinicopathological role of IMP3 expression in GC. These results were validated with an online dataset of 876 patients from the Kaplan-Meier Plotter. Sera from 15 controls and 57 patients with GC were collected in order to compare the levels of serum IMP3 between groups.
High expression of IMP3 was significantly associated with poor prognosis. Survival curves from the Kaplan-Meier Plotter showed that high IMP3 expression was significantly related to worse disease-free survival and overall survival.
Tissue overexpression of IMP3 might be used as a predictor of advanced disease or lymph node metastasis, and is associated with poorer prognosis in GCs. |
| doi_str_mv | 10.21873/anticanres.11298 |
| format | article |
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Tissue microarray blocks with specimens from 346 patients with GC were constructed to evaluate the clinicopathological role of IMP3 expression in GC. These results were validated with an online dataset of 876 patients from the Kaplan-Meier Plotter. Sera from 15 controls and 57 patients with GC were collected in order to compare the levels of serum IMP3 between groups.
High expression of IMP3 was significantly associated with poor prognosis. Survival curves from the Kaplan-Meier Plotter showed that high IMP3 expression was significantly related to worse disease-free survival and overall survival.
Tissue overexpression of IMP3 might be used as a predictor of advanced disease or lymph node metastasis, and is associated with poorer prognosis in GCs.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.11298</identifier><identifier>PMID: 28011483</identifier><language>eng</language><publisher>Greece</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - blood ; Case-Control Studies ; Databases, Factual ; Disease-Free Survival ; Enzyme-Linked Immunosorbent Assay ; Female ; Gastrectomy ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Predictive Value of Tests ; Risk Factors ; RNA-Binding Proteins - analysis ; RNA-Binding Proteins - blood ; Stomach Neoplasms - blood ; Stomach Neoplasms - chemistry ; Stomach Neoplasms - mortality ; Stomach Neoplasms - surgery ; Time Factors ; Tissue Array Analysis ; Treatment Outcome ; Up-Regulation ; Young Adult</subject><ispartof>Anticancer research, 2017-01, Vol.37 (1), p.135-142</ispartof><rights>Copyright© 2017 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-6ad38695f0d70f4def45c7c1cdc86fbab1711791781918632ee9ab2a3b645a33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28011483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Dakeun</creatorcontrib><creatorcontrib>Yu, Eun Ji</creatorcontrib><creatorcontrib>Ham, In-Hye</creatorcontrib><creatorcontrib>Hur, Hoon</creatorcontrib><title>Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>The clinicopathological significance of oncofetal mRNA-binding protein, human insulin-like growth factor II mRNA-binding protein 3 (IMP3), in gastric carcinoma (GC) is not fully understood.
Tissue microarray blocks with specimens from 346 patients with GC were constructed to evaluate the clinicopathological role of IMP3 expression in GC. These results were validated with an online dataset of 876 patients from the Kaplan-Meier Plotter. Sera from 15 controls and 57 patients with GC were collected in order to compare the levels of serum IMP3 between groups.
High expression of IMP3 was significantly associated with poor prognosis. Survival curves from the Kaplan-Meier Plotter showed that high IMP3 expression was significantly related to worse disease-free survival and overall survival.
Tissue overexpression of IMP3 might be used as a predictor of advanced disease or lymph node metastasis, and is associated with poorer prognosis in GCs.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - blood</subject><subject>Case-Control Studies</subject><subject>Databases, Factual</subject><subject>Disease-Free Survival</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Risk Factors</subject><subject>RNA-Binding Proteins - analysis</subject><subject>RNA-Binding Proteins - blood</subject><subject>Stomach Neoplasms - blood</subject><subject>Stomach Neoplasms - chemistry</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - surgery</subject><subject>Time Factors</subject><subject>Tissue Array Analysis</subject><subject>Treatment Outcome</subject><subject>Up-Regulation</subject><subject>Young Adult</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNpFkMtOwzAQRS0EoqXwAWyQl2WRYsdJ7CxL1ZZIBSrUfeQ4TmtI7GC7AsTPkz6A1YxGd45mDgDXGI1CzCi549orwbWVboRxmLIT0Mc0xQGNCToFfRTGKKAIxT1w4dwrQkmSMnIOeiFDGEeM9MH3pFZaCdNyvzG1WXe4GmZNW3eNV0ZDU8FMu22XCmr1JuHcmg-_gTMuvLFBlsHm5Wkc3CtdKr2GS2u8VBoSOMwel-QWTj_b7jq3I3XjOXfeKgEnXAtpL8FZxWsnr451AFaz6WryECye59lkvAgEiSIfJLwkLEnjCpUUVVEpqygWVGBRCpZUBS8wxbuvKcMpZgkJpUx5EXJSJFHMCRmA4QHbWvO-lc7njXJC1jXX0mxdjlkcUhajTtoA4ENUWOOclVXeWtVw-5VjlO-V5__K873ybufmiN8WjSz_Nn4dkx-MEn-T</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Lee, Dakeun</creator><creator>Yu, Eun Ji</creator><creator>Ham, In-Hye</creator><creator>Hur, Hoon</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric Cancer</title><author>Lee, Dakeun ; Yu, Eun Ji ; Ham, In-Hye ; Hur, Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-6ad38695f0d70f4def45c7c1cdc86fbab1711791781918632ee9ab2a3b645a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - blood</topic><topic>Case-Control Studies</topic><topic>Databases, Factual</topic><topic>Disease-Free Survival</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Risk Factors</topic><topic>RNA-Binding Proteins - analysis</topic><topic>RNA-Binding Proteins - blood</topic><topic>Stomach Neoplasms - blood</topic><topic>Stomach Neoplasms - chemistry</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - surgery</topic><topic>Time Factors</topic><topic>Tissue Array Analysis</topic><topic>Treatment Outcome</topic><topic>Up-Regulation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Dakeun</creatorcontrib><creatorcontrib>Yu, Eun Ji</creatorcontrib><creatorcontrib>Ham, In-Hye</creatorcontrib><creatorcontrib>Hur, Hoon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Dakeun</au><au>Yu, Eun Ji</au><au>Ham, In-Hye</au><au>Hur, Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2017-01</date><risdate>2017</risdate><volume>37</volume><issue>1</issue><spage>135</spage><epage>142</epage><pages>135-142</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>The clinicopathological significance of oncofetal mRNA-binding protein, human insulin-like growth factor II mRNA-binding protein 3 (IMP3), in gastric carcinoma (GC) is not fully understood.
Tissue microarray blocks with specimens from 346 patients with GC were constructed to evaluate the clinicopathological role of IMP3 expression in GC. These results were validated with an online dataset of 876 patients from the Kaplan-Meier Plotter. Sera from 15 controls and 57 patients with GC were collected in order to compare the levels of serum IMP3 between groups.
High expression of IMP3 was significantly associated with poor prognosis. Survival curves from the Kaplan-Meier Plotter showed that high IMP3 expression was significantly related to worse disease-free survival and overall survival.
Tissue overexpression of IMP3 might be used as a predictor of advanced disease or lymph node metastasis, and is associated with poorer prognosis in GCs.</abstract><cop>Greece</cop><pmid>28011483</pmid><doi>10.21873/anticanres.11298</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Biomarkers, Tumor - blood Case-Control Studies Databases, Factual Disease-Free Survival Enzyme-Linked Immunosorbent Assay Female Gastrectomy Humans Immunohistochemistry Kaplan-Meier Estimate Male Middle Aged Predictive Value of Tests Risk Factors RNA-Binding Proteins - analysis RNA-Binding Proteins - blood Stomach Neoplasms - blood Stomach Neoplasms - chemistry Stomach Neoplasms - mortality Stomach Neoplasms - surgery Time Factors Tissue Array Analysis Treatment Outcome Up-Regulation Young Adult |
| title | Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric Cancer |
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