Cardiac remodelling amongst adults with various aetiologies of pulmonary arterial hypertension including Eisenmenger syndrome—implications on survival and the role of right ventricular transverse strain

Abstract Aims Survival in pulmonary arterial hypertension (PAH) and Eisenmenger syndrome (ES) relates to right ventricular (RV) function. Little is known about differences of ventricular function between ES patients and those suffering from other PAH aetiologies. In this study, we compared global ve...

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Published in:European heart journal cardiovascular imaging 2017-11, Vol.18 (11), p.1262-1270
Main Authors: Moceri, Pamela, Bouvier, Priscille, Baudouy, Delphine, Dimopoulos, Konstantinos, Cerboni, Pierre, Wort, Stephen J., Doyen, Denis, Schouver, Elie-Dan, Gibelin, Pierre, Senior, Roxy, Gatzoulis, Michael A., Ferrari, Emile, Li, Wei
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Echocardiography, Doppler - methods
Eisenmenger Complex - complications
Eisenmenger Complex - diagnostic imaging
Eisenmenger Complex - mortality
Female
Humans
Hypertension, Pulmonary - diagnostic imaging
Hypertension, Pulmonary - etiology
Hypertension, Pulmonary - mortality
Longitudinal Studies
Male
Middle Aged
Predictive Value of Tests
Prognosis
Prospective Studies
Survival Rate
Ventricular Remodeling
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Summary:Abstract Aims Survival in pulmonary arterial hypertension (PAH) and Eisenmenger syndrome (ES) relates to right ventricular (RV) function. Little is known about differences of ventricular function between ES patients and those suffering from other PAH aetiologies. In this study, we compared global ventricular function assessed by speckle-tracking in adult patients with ES, other PAH aetiologies, or healthy controls; and assessed the relationship between ventricular function and survival. Methods and results We performed a prospective cohort study recruiting 83 adult PAH patients (43 ES and 40 other PAH aetiologies patients) and 37 controls between March 2011 and June 2015. Patients with complex congenital heart disease were excluded. Fifty-three patients (63.9%) were in NYHA functional class ≥III at baseline and 60 (72.3%) were on advanced therapies. Mean RV peak longitudinal strain was −16.3 ± 7% in ES, lower compared with healthy controls (P 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jew277