Association between the Cell Cycle and Neural Crest Delamination through Specific Regulation of G1/S Transition

Delamination of premigratory neural crest cells from the dorsal neural tube depends both upon environmental signals and cell-intrinsic mechanisms and is a prerequisite for cells to engage in migration. Here we show that avian neural crest cells synchronously emigrate from the neural tube in the S ph...

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Bibliographic Details
Published in:Developmental cell 2002-09, Vol.3 (3), p.383-395
Main Authors: Burstyn-Cohen, Tal, Kalcheim, Chaya
Format: Article
Language:English
Subjects:
Animals
Antimetabolites - pharmacology
Bromodeoxyuridine - pharmacology
Cell Cycle - physiology
Cell Differentiation
Cell Movement
Cell Nucleus - physiology
Chick Embryo
Culture Techniques
DNA - biosynthesis
Dose-Response Relationship, Drug
Enzyme Inhibitors - pharmacology
G1 Phase - physiology
Kinetin
Mimosine - pharmacology
Models, Biological
Morphogenesis
MyoD Protein - chemistry
MyoD Protein - metabolism
Neural Crest - cytology
Neural Crest - embryology
Neural Crest - physiology
Purines - pharmacology
Quail - embryology
S Phase - physiology
Transcription Factors - metabolism
Tyrphostins - pharmacology
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Summary:Delamination of premigratory neural crest cells from the dorsal neural tube depends both upon environmental signals and cell-intrinsic mechanisms and is a prerequisite for cells to engage in migration. Here we show that avian neural crest cells synchronously emigrate from the neural tube in the S phase of the cell cycle. Furthermore, specific inhibition of the transition from G1 to S both in ovo and in explants blocks delamination, whereas arrest at the S or G2 phases has no immediate effect. Thus, the events taking place during G1 that control the transition from G1 to S are necessary for the epithelial to mesenchymal conversion of crest precursors.
ISSN:1534-5807
1878-1551
DOI:10.1016/S1534-5807(02)00221-6