Transcriptional and epigenetic phenomena in peripheral blood cells of monozygotic twins discordant for alzheimer’s disease, a case report

Abstract Target genes in Alzheimer’s disease (AD) have been identified. In monozygotic twins discordant for AD we analysed the expression of selected genes, and their possible regulation by epigenetic mechanisms in peripheral blood mononuclear cells, possibly useful to discover biomarkers. Amyloid p...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the neurological sciences 2017-01, Vol.372, p.211-216
Main Authors: D’Addario, Claudio, Candia, Sussy Bastias, Arosio, Beatrice, Di Bartolomeo, Martina, Abbate, Carlo, Casè, Alessandra, Candeletti, Sanzio, Romualdi, Patrizia, Damanti, Sarah, Maccarrone, Mauro, Bergamaschini, Luigi, Mari, Daniela
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - blood
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - genetics
Alzheimer’s disease
Biomarkers - blood
Diseases in Twins - blood
Diseases in Twins - diagnostic imaging
Diseases in Twins - genetics
DNA Methylation
Epigenesis, Genetic
Epigenetic mechanisms
Female
Gene expression
Humans
Leukocytes, Mononuclear
Monozygotic twins
Neurology
Peripheral blood mononuclear cells
Transcription, Genetic
Twins, Monozygotic - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Target genes in Alzheimer’s disease (AD) have been identified. In monozygotic twins discordant for AD we analysed the expression of selected genes, and their possible regulation by epigenetic mechanisms in peripheral blood mononuclear cells, possibly useful to discover biomarkers. Amyloid precursor protein, sirtuin 1 and peptidyl prolyl isomerase 1 gene expressions were highly up-regulated in the AD twin versus the healthy one. Consistently with sirtuin 1 role in controlling acetylation status, we observed a substantial reduction of the acetylation on histone 3 lysine 9, associated with gene transcription in the AD twin. Noteworthy in the AD twin we also observed an increased gene expression in two histone deacetylases (HDACs) isoforms: HDAC2 and HDAC9. A general DNA hypomethylation of all gene promoters studied was also observed in both twins. Our results unravel transcriptional and epigenetic differences potentially helpful to better understand environmental factors and phenotypic differences in monozygotic twins.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2016.11.052