Family history of diabetes and the risk of gestational diabetes mellitus in Iran: A systematic review and meta-analysis

Abstract Objective Gestational diabetes is the most prevalent metabolic disorder being firstly diagnosed during pregnancy. The relationship between the family history of diabetes and the gestational diabetes mellitus (GDM) has been investigated in several primary studies with a number of contradicti...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2017-11, Vol.11, p.S99-S104
Main Authors: Moosazadeh, Mahmood, Asemi, Zatollah, Lankarani, Kamran B, Tabrizi, Reza, Maharlouei, Najmeh, Naghibzadeh-Tahami, Ahmad, Yousefzadeh, Gholamreza, Sadeghi, Reza, Khatibi, Seyed Reza, Afshari, Mahdi, Khodadost, Mahmoud, Akbari, Maryam
Format: Article
Language:English
Subjects:
Diabetes
Diabetes Mellitus, Type 2 - complications
Diabetes, Gestational - etiology
Endocrinology & Metabolism
Family history of diabetes
Female
Genetic Predisposition to Disease
Gestational diabetes mellitus
Humans
Iran
Meta-analysis
Pregnancy
Prognosis
Risk Factors
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Summary:Abstract Objective Gestational diabetes is the most prevalent metabolic disorder being firstly diagnosed during pregnancy. The relationship between the family history of diabetes and the gestational diabetes mellitus (GDM) has been investigated in several primary studies with a number of contradictions in the results. Hence, the purpose of the present study is to determine the relationship between the GDM and the family history of diabetes using the meta-analysis method. Method All published papers in main national and international databases were systematically searched with some specific keywords to find the related studies between 2000 and 2016. We calculated the odds ratio (OR) with 95% confidence interval (CI) in analysis for each study using a random-effect and Mantel-Haenzel method. We also determined heterogeneity among these 33 articles and their publication bias. Results We entered 33 relevant studies of 2516 articles into the meta-analysis process including 2697 women with family history of diabetes mellitus as well as 29134 women without. Of them, 954 and 4372 subjects developed GDM respectively. Combining the results of the primary studies using the meta-analysis method, the overall odds ratio of family history for developing GDM was estimated as of 3.46 (95% CI: 2.80–4.27). Conclusion This meta-analysis study revealed that the family history of diabetes is an important risk factor for the gestational diabetes mellitus.
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2016.12.016