Non-invasive PET imaging of brain inflammation at disease onset predicts spontaneous recurrent seizures and reflects comorbidities

Highlights • KASE rats display depression-like and sensorimotor-related comorbidities. • Translocator protein PET imaging correlates severity of depression-like and sensorimotor-related comorbidities. • Translocator protein PET imaging predicts spontaneous seizure frequency. • Non-invasive PET imagi...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2017-03, Vol.61, p.69-79
Main Authors: Bertoglio, Daniele, Verhaeghe, Jeroen, Santermans, Eva, Amhaoul, Halima, Jonckers, Elisabeth, Wyffels, Leonie, Van Der Linden, Annemie, Hens, Niel, Staelens, Steven, Dedeurwaerdere, Stefanie
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Biomarker
Brain - diagnostic imaging
Comorbidity
Disease Progression
Electroencephalography
Encephalitis - diagnostic imaging
Epileptogenesis
Male
PET
Positron-Emission Tomography
Predictive Value of Tests
Psychiatry
Rats
Rats, Wistar
Recurrence
Seizures - diagnostic imaging
Spontaneous recurrent seizures
Status Epilepticus - diagnostic imaging
Translocator protein
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Summary:Highlights • KASE rats display depression-like and sensorimotor-related comorbidities. • Translocator protein PET imaging correlates severity of depression-like and sensorimotor-related comorbidities. • Translocator protein PET imaging predicts spontaneous seizure frequency. • Non-invasive PET imaging is a prognostic biomarker for seizure frequency and reflects severity of investigated comorbidities.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.12.015