Aromatase changes in depression: A postmortem and animal experimental study

Highlights • Depression is characterized by a hyperactive hypothalamo-pituitary-adrenal (HPA) axis. • Increased aromatase was hypothesized for explaining sex-steroid-dependent HPA activation. • However, decreased hypothalamic aromatase expression was observed in major depression. • Aromatase inhibit...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2017-03, Vol.77, p.56-62
Main Authors: Wu, Juan-Li, He, Yang, Hrubý, Radovan, Balesar, Rawien, Qi, Yang-Jian, Guo, Lei, Ren, Zhong, Zhu, Qiong-Bin, Huang, Man-Li, Swaab, Dick F, Bao, Ai-Min
Format: Article
Language:English
Subjects:
1,4,6-Androstatriene-3,17-dione
Aged
Aged, 80 and over
Androstatrienes - pharmacology
Animals
Aromatase
Aromatase - metabolism
Aromatase Inhibitors - pharmacology
Chronic unpredictable mild stress
Depression
Depressive Disorder, Major - metabolism
Disease Models, Animal
Endocrinology & Metabolism
Female
Humans
Hypothalamo-Hypophyseal System - metabolism
Immunohistochemistry
Male
Middle Aged
Paraventricular Hypothalamic Nucleus - drug effects
Paraventricular Hypothalamic Nucleus - metabolism
Paraventricular nucleus
Pituitary-Adrenal System - metabolism
Psychiatry
Rats
Stress, Psychological - metabolism
Testosterone - blood
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Summary:Highlights • Depression is characterized by a hyperactive hypothalamo-pituitary-adrenal (HPA) axis. • Increased aromatase was hypothesized for explaining sex-steroid-dependent HPA activation. • However, decreased hypothalamic aromatase expression was observed in major depression. • Aromatase inhibitor administration did not change depression-symptoms in a rat model. • Aromatase changes in adulthood do not play a key role in the symptoms of depression.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.11.026