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Allogenic cultivated limbal stem cell transplantation versus cadaveric keratolimbal allograft in ocular surface disorder: 1-year outcome

Purpose To compare the outcome of allogenic ex vivo cultivated limbal stem cell transplantation (LSCT) versus cadaveric keratolimbal allograft in patients with limbal stem cell deficiency (LSCD). Methods In this prospective interventional study from Army Hospital Research and Referral in New Delhi,...

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Published in:International ophthalmology 2017-12, Vol.37 (6), p.1323-1331
Main Authors: Parihar, Jitendra Kumar Singh, Parihar, Avinash Singh, Jain, Vaibhav Kumar, Kaushik, Jaya, Nath, Pramod
Format: Article
Language:English
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Summary:Purpose To compare the outcome of allogenic ex vivo cultivated limbal stem cell transplantation (LSCT) versus cadaveric keratolimbal allograft in patients with limbal stem cell deficiency (LSCD). Methods In this prospective interventional study from Army Hospital Research and Referral in New Delhi, 50 eyes of 40 patients with ocular surface disorder having LSCD underwent either cultivated LSCT (group 1: 25 eyes of 20 patients) or keratolimbal allograft transplantation (group 2: 25 eyes of 20 patients). The outcome measures were gain of two or more lines of best-corrected visual acuity (BCVA), absence of conjunctival vascularization over cornea, corneal neovascularization regression, regression of visually significant corneal opacity (iris details poorly visible), Schirmer’s 1 ≥10 s, tear break-up time (TBUT) ≥10 s, and absence of fluorescein staining. Results At 1 year of follow-up, both groups experienced significant improvement in all outcome measures, but there was no significant difference between both groups in improvement of two or more lines of BCVA ( P  = 0.841), absence of conjunctival vascularization over cornea ( P  = 0.812), corneal neovascularization ( P  = 0.074), visually significant corneal opacity ( P  = 0.075), Schirmer’s 1 ≥10 s ( P  = 0.814), TBUT ≥10 s ( P  = 0.382), or absence of fluorescein stain ( P  = 1.00). Conclusion Both allogenic ex vivo cultivated LSCT and cadaveric keratolimbal allograft transplantation are comparable in terms of visual gain and ocular surface restoration.
ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-016-0415-0