Th17 cells correlate positively to the structural and functional integrity of the brain in bipolar depression and healthy controls

Highlights • Frequency of Th17 correlated to higher coherence of white matter microstructure. • Frequency of T regulatory cells correlated to a reduced coherence of fiber tracts. • Frequency of T regulatory cells correlated to lower BOLD responses to moral stimuli.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2017-03, Vol.61, p.317-325
Main Authors: Poletti, Sara, de Wit, Harm, Mazza, Elena, Wijkhuijs, Annemarie J.M, Locatelli, Clara, Aggio, Veronica, Colombo, Cristina, Benedetti, Francesco, Drexhage, Hemmo A
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Anisotropy
Bipolar disorder
Bipolar Disorder - diagnostic imaging
Bipolar Disorder - immunology
Brain - diagnostic imaging
Brain - immunology
Diffusion Tensor Imaging
Female
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuro-inflammation
Neuroimaging
Psychiatry
T cells
T-Lymphocyte Subsets - immunology
T-Lymphocytes, Regulatory - immunology
Th17 Cells - immunology
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Description
Summary:Highlights • Frequency of Th17 correlated to higher coherence of white matter microstructure. • Frequency of T regulatory cells correlated to a reduced coherence of fiber tracts. • Frequency of T regulatory cells correlated to lower BOLD responses to moral stimuli.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.12.020