Lysosomal degradation of intracellular nucleic acids-multiple autophagic pathways

Cell metabolism can be considered as a process of serial construction and destruction of cellular components, both of which must be regulated accurately. In eukaryotic cells, a variety of cellular components are actively delivered into lysosomes/vacuoles, specialized compartments for hydrolysis of m...

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Bibliographic Details
Published in:Journal of biochemistry (Tokyo) 2017-02, Vol.161 (2), p.145-154
Main Authors: Fujiwara, Yuuki, Wada, Keiji, Kabuta, Tomohiro
Format: Article
Language:English
Subjects:
Animals
Autophagosomes - metabolism
Autophagy - physiology
Humans
Intracellular Space - metabolism
Lysosomes - metabolism
Models, Biological
Nucleic Acids - metabolism
Signal Transduction
Vacuoles - metabolism
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Summary:Cell metabolism can be considered as a process of serial construction and destruction of cellular components, both of which must be regulated accurately. In eukaryotic cells, a variety of cellular components are actively delivered into lysosomes/vacuoles, specialized compartments for hydrolysis of macromolecules. Such processes of 'self-eating' are called autophagy. Despite a wide variety of lysosomal/vacuolar hydrolases, much of the interest has been focused on the proteolytic functions of autophagy and less attention has been devoted to the degradation of other macromolecules such as nucleic acids. In this review, we focus on delivery and degradation of endogenous nucleic acids by autophagic systems, and discuss their molecular mechanisms and physiological/pathophysiological roles.
ISSN:0021-924X
1756-2651
DOI:10.1093/jb/mvw085