mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene ( HIF1A ): an independent predictor of poor overall survival in chronic lymphocytic leukemia

Highlights • A cost-effective qPCR method for quantification of HIF1A mRNA levels was developed. • HIF1A mRNA levels do not differ between normal blood samples and leukemic B cells. • High HIF1A mRNA expression predicts poor overall survival in CLL patients. • Prognostic significance of HIF1A mRNA i...

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Bibliographic Details
Published in:Leukemia research 2017-02, Vol.53, p.65-73
Main Authors: Kontos, Christos K, Papageorgiou, Sotirios G, Diamantopoulos, Marios A, Scorilas, Andreas, Bazani, Efthimia, Vasilatou, Diamantina, Gkontopoulos, Konstantinos, Glezou, Eirini, Stavroulaki, Georgia, Dimitriadis, George, Pappa, Vasiliki
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - blood
Case-Control Studies
CLL
Hematological malignancy
Hematology, Oncology and Palliative Medicine
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell - mortality
Prognosis
Prognostic biomarker
Real-time PCR
RNA, Messenger - analysis
Survival Rate
Tumor marker
Unfavorable prognosis
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Summary:Highlights • A cost-effective qPCR method for quantification of HIF1A mRNA levels was developed. • HIF1A mRNA levels do not differ between normal blood samples and leukemic B cells. • High HIF1A mRNA expression predicts poor overall survival in CLL patients. • Prognostic significance of HIF1A mRNA is independent of clinicopathological factors. • HIF1A mRNA is an unfavorable prognosticator in distinct subgroups of CLL patients.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2016.11.014