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mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene ( HIF1A ): an independent predictor of poor overall survival in chronic lymphocytic leukemia
Highlights • A cost-effective qPCR method for quantification of HIF1A mRNA levels was developed. • HIF1A mRNA levels do not differ between normal blood samples and leukemic B cells. • High HIF1A mRNA expression predicts poor overall survival in CLL patients. • Prognostic significance of HIF1A mRNA i...
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| Published in: | Leukemia research 2017-02, Vol.53, p.65-73 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c420t-454aa555c2321ecd06a2b970bb8e84ca4fe34e261ecdf25f5bc0d9b76e65f0103 |
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| cites | cdi_FETCH-LOGICAL-c420t-454aa555c2321ecd06a2b970bb8e84ca4fe34e261ecdf25f5bc0d9b76e65f0103 |
| container_end_page | 73 |
| container_issue | |
| container_start_page | 65 |
| container_title | Leukemia research |
| container_volume | 53 |
| creator | Kontos, Christos K Papageorgiou, Sotirios G Diamantopoulos, Marios A Scorilas, Andreas Bazani, Efthimia Vasilatou, Diamantina Gkontopoulos, Konstantinos Glezou, Eirini Stavroulaki, Georgia Dimitriadis, George Pappa, Vasiliki |
| description | Highlights • A cost-effective qPCR method for quantification of HIF1A mRNA levels was developed. • HIF1A mRNA levels do not differ between normal blood samples and leukemic B cells. • High HIF1A mRNA expression predicts poor overall survival in CLL patients. • Prognostic significance of HIF1A mRNA is independent of clinicopathological factors. • HIF1A mRNA is an unfavorable prognosticator in distinct subgroups of CLL patients. |
| doi_str_mv | 10.1016/j.leukres.2016.11.014 |
| format | article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-454aa555c2321ecd06a2b970bb8e84ca4fe34e261ecdf25f5bc0d9b76e65f0103</citedby><cites>FETCH-LOGICAL-c420t-454aa555c2321ecd06a2b970bb8e84ca4fe34e261ecdf25f5bc0d9b76e65f0103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28038356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kontos, Christos K</creatorcontrib><creatorcontrib>Papageorgiou, Sotirios G</creatorcontrib><creatorcontrib>Diamantopoulos, Marios A</creatorcontrib><creatorcontrib>Scorilas, Andreas</creatorcontrib><creatorcontrib>Bazani, Efthimia</creatorcontrib><creatorcontrib>Vasilatou, Diamantina</creatorcontrib><creatorcontrib>Gkontopoulos, Konstantinos</creatorcontrib><creatorcontrib>Glezou, Eirini</creatorcontrib><creatorcontrib>Stavroulaki, Georgia</creatorcontrib><creatorcontrib>Dimitriadis, George</creatorcontrib><creatorcontrib>Pappa, Vasiliki</creatorcontrib><title>mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene ( HIF1A ): an independent predictor of poor overall survival in chronic lymphocytic leukemia</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Highlights • A cost-effective qPCR method for quantification of HIF1A mRNA levels was developed. • HIF1A mRNA levels do not differ between normal blood samples and leukemic B cells. • High HIF1A mRNA expression predicts poor overall survival in CLL patients. • Prognostic significance of HIF1A mRNA is independent of clinicopathological factors. • HIF1A mRNA is an unfavorable prognosticator in distinct subgroups of CLL patients.</description><subject>Biomarkers, Tumor - blood</subject><subject>Case-Control Studies</subject><subject>CLL</subject><subject>Hematological malignancy</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - genetics</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - mortality</subject><subject>Prognosis</subject><subject>Prognostic biomarker</subject><subject>Real-time PCR</subject><subject>RNA, Messenger - analysis</subject><subject>Survival Rate</subject><subject>Tumor marker</subject><subject>Unfavorable prognosis</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFUk1v1DAQtRCILoWfAPKxHBI8TuzNcgCtKkorVSDxcbYcZ8J668SpnayaH8T_xGEXDly4eDz2e28084aQl8ByYCDf7HOH013AmPOU5gA5g_IRWUG1LjJRFeIxWaUXkXHg8ow8i3HPGBMb2DwlZ7xiRYLIFfnZffm0pf6AAR-GpBat76lv6bhDupsH_2A1tX0zGVs7pK02ow8UqHbDTtM41VNvR_oDe6QX9PrmCrb09Vuq-4WDA6ajH2nSbexvYhIe_BJTPe1cEggHe9AuwanZBd9bQ93cDTtv5nG5pxaxs_o5edJqF_HFKZ6T71cfvl1eZ7efP95cbm8zU3I2ZqUotRZCGF5wQNMwqXm9WbO6rrAqjS5bLErkcvlruWhFbVizqdcSpWgZsOKcXBx1h-DvJ4yj6mw06Jzu0U9RQSVKCZKtywQVR6gJPsaArRqC7XSYFTC1OKT26uSQWhxSACr5kXivTiWmusPmL-uPJQnw_gjA1OjBYlDRWOxNmmFAM6rG2_-WePePgnE2jVa7O5wx7v0U-jRFBSpyxdTXZU2WLQFZMC4ZK34BSjO8Ug</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Kontos, Christos K</creator><creator>Papageorgiou, Sotirios G</creator><creator>Diamantopoulos, Marios A</creator><creator>Scorilas, Andreas</creator><creator>Bazani, Efthimia</creator><creator>Vasilatou, Diamantina</creator><creator>Gkontopoulos, Konstantinos</creator><creator>Glezou, Eirini</creator><creator>Stavroulaki, Georgia</creator><creator>Dimitriadis, George</creator><creator>Pappa, Vasiliki</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170201</creationdate><title>mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene ( HIF1A ): an independent predictor of poor overall survival in chronic lymphocytic leukemia</title><author>Kontos, Christos K ; 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| fulltext | fulltext |
| identifier | ISSN: 0145-2126 |
| ispartof | Leukemia research, 2017-02, Vol.53, p.65-73 |
| issn | 0145-2126 1873-5835 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Biomarkers, Tumor - blood Case-Control Studies CLL Hematological malignancy Hematology, Oncology and Palliative Medicine Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - mortality Prognosis Prognostic biomarker Real-time PCR RNA, Messenger - analysis Survival Rate Tumor marker Unfavorable prognosis |
| title | mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene ( HIF1A ): an independent predictor of poor overall survival in chronic lymphocytic leukemia |
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