Determinants of gentamicin concentrations in critically ill patients: a population pharmacokinetic analysis

Highlights • Gentamicin pharmacokinetics are highly variable in critically ill patients. • Albumin and creatinine clearance are major covariates for gentamicin concentration. • Higher starting gentamicin doses may be needed for patients with hypoalbuminaemia. • Serum creatinine and the Cockcroft–Gau...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2017-02, Vol.49 (2), p.204-211
Main Authors: Hodiamont, Caspar J, Juffermans, Nicole P, Bouman, Catherine S.C, de Jong, Menno D, Mathôt, Ron A.A, van Hest, Reinier M
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Creatinine - blood
Creatinine - metabolism
Critical Illness
Female
Gentamicin
Gentamicins - administration & dosage
Gentamicins - pharmacokinetics
Humans
Hypoalbuminaemia
Infectious Disease
Intensive Care Units
Kidney Function Tests
Male
Metabolic Clearance Rate
Middle Aged
Population pharmacokinetics
Renal function
Retrospective Studies
Serum - chemistry
Serum Albumin - analysis
Young Adult
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Summary:Highlights • Gentamicin pharmacokinetics are highly variable in critically ill patients. • Albumin and creatinine clearance are major covariates for gentamicin concentration. • Higher starting gentamicin doses may be needed for patients with hypoalbuminaemia. • Serum creatinine and the Cockcroft–Gault formula overestimate gentamicin clearance. • Urinary creatinine clearance correlates best with gentamicin clearance.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2016.10.022