Pulmonary Sarcomatoid Carcinoma: An Analysis of the National Cancer Data Base

Abstract Introduction Pulmonary sarcomatoid carcinoma (PSC) is a grouping of five rare non-small cell lung cancer (NSCLC) subtypes. We studied the clinical characteristics and outcomes of PSC utilizing the National Cancer Data Base (NCDB), an oncology outcomes database. Methods The NCDB lung cancer...

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Published in:Clinical lung cancer 2017-05, Vol.18 (3), p.286-292
Main Authors: Steuer, Conor E, Behera, Madhusmita, Liu, Yuan, Fu, Chao, Gillespie, Theresa W, Saba, Nabil F, Shin, Dong M, Pillai, Rathi N, Pakkala, Suchita, Owonikoko, Taofeek K, Khuri, Fadlo R, Ramalingam, Suresh S
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Non-Small-Cell Lung - epidemiology
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Continental Population Groups
Databases, Factual
Female
Hematology, Oncology and Palliative Medicine
Humans
Lung cancer
Lung Neoplasms - epidemiology
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Male
NCDB
Neoplasm Staging
NSCLC
Outcomes
Prevalence
Pulmonary/Respiratory
Retrospective Studies
Risk
Sarcoma - epidemiology
Sarcoma - mortality
Sarcoma - pathology
Sarcomatoid
Survival Analysis
United States - epidemiology
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Summary:Abstract Introduction Pulmonary sarcomatoid carcinoma (PSC) is a grouping of five rare non-small cell lung cancer (NSCLC) subtypes. We studied the clinical characteristics and outcomes of PSC utilizing the National Cancer Data Base (NCDB), an oncology outcomes database. Methods The NCDB lung cancer database was queried from 1998 to 2011 for PSC using ICD-O-3 codes. Data were extracted on patient demographics, tumor pathology, treatments, and outcomes. Overall survival (OS) data were available for patients diagnosed from 1998-2006 and co-morbidity data from 2003-2011. Univariate association with covariates between PSC and other forms of NSCLC was assessed using Chi-square test or ANOVA, where appropriate. Results Of the 1,547,531 NSCLC patients in the NCDB from 1998-2011, 7965 were identified with PSC (0.5%). PSC patients had a median age of 70, 59% male, and 89% Caucasian. At presentation, 18% were AJCC stage I, 10% stage II, 24% stage III, and 48% stage IV. The median OS for stage I-II PSC was 16.9 months, 5.8 months for stage III, and 5.4 months for stage IV. There was a higher risk of death on multivariate analysis for PSC patients in comparison to other histologic subtypes of NSCLC both in all patients (hazard ratio (HR) 1.34 (95% CI 1.20-1.48) p
ISSN:1525-7304
1938-0690
DOI:10.1016/j.cllc.2016.11.016