Sperm-bound antisperm antibodies prevent capacitation of bovine spermatozoa

It was hypothesized here that sperm-bound antisperm antibodies (ASAs) impair the ability of bovine spermatozoa to undergo capacitation, bind to the zona pellucida, and complete the acrosome reaction. The effect of ASA binding on these functions was evaluated in frozen/thawed spermatozoa from four bu...

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Bibliographic Details
Published in:Theriogenology 2017-02, Vol.89, p.58-67
Main Authors: Ferrer, M.S., Klabnik-Bradford, J., Anderson, D.E., Bullington, A.C., Palomares, R.A., Miller, L.M.J., Stawicki, R., Miesner, M.
Format: Article
Language:English
Subjects:
Acrosome reaction
Acrosome Reaction - physiology
Animals
Antisperm antibodies
Bovine
Calcium Ionophores - pharmacology
Capacitation
Cattle - immunology
Cell Membrane - immunology
Female
Freezing
Heparin - pharmacology
Immunoglobulin A - immunology
Immunoglobulin G - immunology
Male
Sperm Capacitation - immunology
Spermatozoa - drug effects
Spermatozoa - immunology
Zona binding
Zona Pellucida - physiology
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Summary:It was hypothesized here that sperm-bound antisperm antibodies (ASAs) impair the ability of bovine spermatozoa to undergo capacitation, bind to the zona pellucida, and complete the acrosome reaction. The effect of ASA binding on these functions was evaluated in frozen/thawed spermatozoa from four bulls before and after induction of ASAs. Ejaculates were divided into ASA negative (
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2016.10.012