Estimated glomerular filtration rate (eGFR), 25(OH) D3, chronic kidney disease (CKD), the MYH9 (myosin heavy chain 9) gene in old and very elderly people

It is known that the common physiological denominator of the ageing process is an attenuation of functional performance with respect to the situation of young people and adults. However, since the first cohort-based longitudinal studies, it has not been possible to establish a “linear” relationship...

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Published in:International urology and nephrology 2015-08, Vol.47 (8), p.1403-1408
Main Authors: Otero Gonzalez, A., Prol, M. P. Borrajo, Caride, M. J. Camba, Nores, J. Santos, Novoa, E., Melon, C. Perez, Macia, P., Alves, M. T., Cid, M., Osorio, E., Coto, E., Macias Nuñez, J. F.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Aging
Biomarkers - blood
Calcifediol - blood
DNA - genetics
Female
Glomerular Filtration Rate - physiology
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Molecular Motor Proteins - genetics
Molecular Motor Proteins - metabolism
Myosin Heavy Chains - genetics
Myosin Heavy Chains - metabolism
Nephrology
Nephrology - Original Paper
Polymorphism, Genetic
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - genetics
Renal Insufficiency, Chronic - physiopathology
Risk Factors
Urology
Young Adult
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creator Otero Gonzalez, A.
Prol, M. P. Borrajo
Caride, M. J. Camba
Nores, J. Santos
Novoa, E.
Melon, C. Perez
Macia, P.
Alves, M. T.
Cid, M.
Osorio, E.
Coto, E.
Macias Nuñez, J. F.
description It is known that the common physiological denominator of the ageing process is an attenuation of functional performance with respect to the situation of young people and adults. However, since the first cohort-based longitudinal studies, it has not been possible to establish a “linear” relationship between age and glomerular filtration in all cases. This does not mean that there is no physiological ageing process at all; in addition to those already elucidated, its mechanisms include cell senescence, podocyte dysfunction, a vitamin D deficiency, and homozygotic forms of the MYH9 gene. The aim of the present work was to analyse the prevalence of chronic kidney disease (CKD) and, where possible, the correlation between CKD, defined by an eGFR 
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This does not mean that there is no physiological ageing process at all; in addition to those already elucidated, its mechanisms include cell senescence, podocyte dysfunction, a vitamin D deficiency, and homozygotic forms of the MYH9 gene. The aim of the present work was to analyse the prevalence of chronic kidney disease (CKD) and, where possible, the correlation between CKD, defined by an eGFR &lt; 60 ml/min/1.73 m 2 , plasma 25(OH)D3 levels and the MYH9 gene in a population of elderly and very elderly persons. These parameters have not been evaluated previously in populations of elderly and very elderly patients. It is concluded that a moderate decrease in the eGFR occurs with age. This does not imply the presence of CKD in elderly people, since in most individuals the reduced eGFR is not accompanied by anaemia, and no individuals show hypocalcaemia, hyperphosphataemia or a high Alb/Cr ratio. Here we observed a lower Hb level and an elevated Alb/Cr ratio in subjects heterozygotic for the MYH9 gene. 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subjects Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Aging
Biomarkers - blood
Calcifediol - blood
DNA - genetics
Female
Glomerular Filtration Rate - physiology
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Molecular Motor Proteins - genetics
Molecular Motor Proteins - metabolism
Myosin Heavy Chains - genetics
Myosin Heavy Chains - metabolism
Nephrology
Nephrology - Original Paper
Polymorphism, Genetic
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - genetics
Renal Insufficiency, Chronic - physiopathology
Risk Factors
Urology
Young Adult
title Estimated glomerular filtration rate (eGFR), 25(OH) D3, chronic kidney disease (CKD), the MYH9 (myosin heavy chain 9) gene in old and very elderly people
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