The significance of rotational behavior and sensitivity of striatal dopamine receptors in hemiparkinsonian rats: A comparative study of lactacystin and 6-OHDA

Highlights • Lactacystin and 6-OHDA produced similar declines in DA level in the striatum and SN. • Both PD models did not differ in the intensity of amphetamine-induced rotations. • Contralateral rotations after apomorphine were not observed in the lactacystin model. • DA D2 receptor binding was in...

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Bibliographic Details
Published in:Neuroscience 2017-01, Vol.340, p.308-318
Main Authors: Konieczny, Jolanta, Czarnecka, Anna, Lenda, Tomasz, Kamińska, Kinga, Antkiewicz-Michaluk, Lucyna
Format: Article
Language:English
Subjects:
6-OHDA
Acetylcysteine - analogs & derivatives
amphetamine
Amphetamine - pharmacology
Animals
apomorphine
Apomorphine - pharmacology
Benzazepines - pharmacology
Central Nervous System Stimulants - pharmacology
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Dopamine - metabolism
Dopamine Agents - pharmacology
dopamine receptors
Dose-Response Relationship, Drug
Functional Laterality - physiology
lactacystin
Male
Motor Activity - drug effects
Motor Activity - physiology
Neurology
Oxidopamine
Parkinsonian Disorders - metabolism
Pars Compacta - drug effects
Pars Compacta - metabolism
Raclopride - pharmacology
Rats, Wistar
Receptors, Dopamine D1 - metabolism
Receptors, Dopamine D2 - metabolism
Rotation
rotational behavior
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Summary:Highlights • Lactacystin and 6-OHDA produced similar declines in DA level in the striatum and SN. • Both PD models did not differ in the intensity of amphetamine-induced rotations. • Contralateral rotations after apomorphine were not observed in the lactacystin model. • DA D2 receptor binding was increased in the lesioned striatum in both PD models. • Striatal DA D1 receptor binding was increased bilaterally only following 6-OHDA.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.10.070