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Serotonin and urocortin 1 in the dorsal raphe and Edinger-Westphal nuclei after early life stress in serotonin transporter knockout rats
Highlights • Early life stress (ELS) increases 5-HT1A expression in the Edinger-Westphal nuclei (EWcp) • ELS and serotonin transporter (5-HTT) genotype affect DNA methylation of the urocortin 1 gene in the EWcp. • 5-HTT deficiency is associated with decreased 5-HT innervation of EWcp-urocortin 1 neu...
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| Published in: | Neuroscience 2017-01, Vol.340, p.345-358 |
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| container_start_page | 345 |
| container_title | Neuroscience |
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| creator | van der Doelen, Rick H.A Robroch, Berit Arnoldussen, Ilse A Schulpen, Maya Homberg, Judith R Kozicz, Tamás |
| description | Highlights • Early life stress (ELS) increases 5-HT1A expression in the Edinger-Westphal nuclei (EWcp) • ELS and serotonin transporter (5-HTT) genotype affect DNA methylation of the urocortin 1 gene in the EWcp. • 5-HTT deficiency is associated with decreased 5-HT innervation of EWcp-urocortin 1 neurons. • ELS is associated with an increased number of 5-HT neurons in the lateral wings of the dorsal raphe nucleus. |
| doi_str_mv | 10.1016/j.neuroscience.2016.10.072 |
| format | article |
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| subjects | 5-HT receptor 1A Animals corticotropin-releasing factor receptor depression DNA Methylation Dorsal Raphe Nucleus - growth & development Dorsal Raphe Nucleus - metabolism Edinger-Westphal Nucleus - growth & development Edinger-Westphal Nucleus - metabolism Female Male Maternal Deprivation maternal separation Neurology Promoter Regions, Genetic Ranolazine Rats, Transgenic Rats, Wistar Receptor, Serotonin, 5-HT1A - metabolism Receptors, Corticotropin-Releasing Hormone - metabolism Receptors, Glucocorticoid - metabolism RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Serotonin - metabolism serotonin transporter Stress, Psychological - metabolism Urocortins - genetics Urocortins - metabolism |
| title | Serotonin and urocortin 1 in the dorsal raphe and Edinger-Westphal nuclei after early life stress in serotonin transporter knockout rats |
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