Structural Analysis and Application of n-Alkyl Cyanoacrylate Surgical Adhesives to the Fixation of Meshes for Hernia Repair

• Published in: Macromolecular bioscience 2016-12, Vol.16 (12), p.1803-1814
• Main Authors: Fernández-Gutiérrez, Mar, Rodriguez-Mancheño, Marta, Pérez-Köhler, Bárbara, Pascual, Gemma, Bellón, Juan Manuel, Román, Julio San
• Format: Article
• Language: English
• Subjects: akyl cyanoacrylates; Animals; Biomechanical Phenomena; Cell Adhesion - drug effects; Cell Proliferation - drug effects; Cells, Cultured; Cyanoacrylates - administration & dosage; Cyanoacrylates - chemistry; cyanoacrylic adhesives; Fibroblasts - cytology; Fibroblasts - drug effects; hernia repair; Hernia, Abdominal - surgery; Herniorrhaphy - methods; Humans; Macrophages - cytology; Macrophages - drug effects; Male; Models, Animal; Polymerization; Polypropylenes - chemistry; Prosthesis Design; Rabbits; Skin - cytology; Skin - drug effects; Surgical Mesh; Tissue Adhesives - chemistry; Tissue Adhesives - pharmacology
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.201600246

The article deals with a comparative analysis of the parameters of the polymerization in physiological conditions of three commercially available alkyl cyanoacrylates, n‐butyl cyanoacrylate (GLUBRAN 2), n‐hexyl cyanoacrylate (IFABOND), and n‐octyl cyanoacrylate (EVOBOND), the cell behavior of the corresponding polymers and the application of these adhesives in the fixation of surgical polypropylene meshes for hernia repair in an animal model of rabbits. The results obtained demonstrate that the curing process depends on the nature of the alkyl residue of the ester group of cyanoacrylate molecules, being the heat of polymerization lower for the octyl derivative in comparison with the hexyl and butyl, and reaching a maximum temperature of 35 °C after a time of mixing with physiological fluids of 60–70 s. The cell behavior demonstrates that the three systems do not present toxicity for fibroblasts and low adhesion of cells, which is a positive result for application as tissue adhesives, especially for the fixation of abdominal polypropylene meshes for hernia repair. The animal experimentation indicates the excellent tolerance of the meshes fixed with the cyanoacrylic adhesives, during at least a period of 90 d, and guarantees a good adhesion for the application of hernia repair meshes. This work deals with the study of the physicochemical characteristics of the three more relevant cyanoacrylate adhesives, n‐butyl (GLUBRAN 2), n‐hexyl (IFABOND), and n‐octyl (EVOBOND) cyanoacrylates considering the heat associated to the curing process, the properties of the glues or adhesion of modern high density polypropylene meshes for hernia repair, and the biological behavior of at the cellular level.