Clinical usefulness of international normalized ratio calibration of prothrombin time in patients with chronic liver disease

The international normalized ratio (INR) may not be directly applicable to patients with liver disease. We aimed to establish an alternative INR calibration system for patients with liver disease and to evaluate the effect of their use in chronic liver disease patients. Eighty-two patients with live...

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Bibliographic Details
Published in:International journal of hematology 2015-08, Vol.102 (2), p.163-169
Main Authors: Lee, Jun Hyung, Kweon, Oh Joo, Lee, Mi-Kyung, Lee, Hyun Woong, Kim, Hyung Joon, Kim, Hye Ryoun
Format: Article
Language:English
Subjects:
Aged
Chronic Disease
Female
Hematology
Humans
International Normalized Ratio
Liver Cirrhosis - blood
Liver Cirrhosis - etiology
Liver Diseases - blood
Liver Diseases - diagnosis
Liver Diseases - etiology
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Prothrombin Time - methods
Prothrombin Time - standards
Reference Values
Thromboplastin
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Summary:The international normalized ratio (INR) may not be directly applicable to patients with liver disease. We aimed to establish an alternative INR calibration system for patients with liver disease and to evaluate the effect of their use in chronic liver disease patients. Eighty-two patients with liver cirrhosis (LC) were included, and their prothrombin times (PTs) were measured by using 5 commercial thromboplastins. Each of the thromboplastins was also assigned an international sensitivity index (ISI liver ) by the plasmas from LC patients. INR vka , INR liver , model for end-stage liver disease (MELD) vka , MELD liver , Child-Pugh (Child) vka , and Child liver scores were calculated. The coefficient of variance of INR vka was significantly larger than that of INR liver ( P  
ISSN:0925-5710
1865-3774
DOI:10.1007/s12185-015-1820-2