Individual changes in preclinical spinocerebellar ataxia identified via increased motor complexity

ABSTRACT Background Movement changes in autosomal‐dominant spinocerebellar ataxias are suggested to occur many years before clinical manifestation. Detecting and quantifying these changes in the preclinical phase offers a window for future treatment interventions and allows the clinician to decipher...

Full description

Saved in:
Bibliographic Details
Published in:Movement disorders 2016-12, Vol.31 (12), p.1891-1900
Main Authors: Ilg, Winfried, Fleszar, Zofia, Schatton, Cornelia, Hengel, Holger, Harmuth, Florian, Bauer, Peter, Timmann, Dagmar, Giese, Martin, Schöls, Ludger, Synofzik, Matthis
Format: Article
Language:English
Subjects:
Adult
Aged
Biomechanical Phenomena - physiology
Cross-Sectional Studies
Female
Gait Disorders, Neurologic - etiology
Gait Disorders, Neurologic - genetics
Gait Disorders, Neurologic - physiopathology
Heterozygote
Humans
Male
Middle Aged
Movement disorders
multivariate analysis
Mutation
Postural Balance - physiology
preclinical stage
movement analysis
quantitative motor features
spinocerebellar ataxia
Spinocerebellar Ataxias - complications
Spinocerebellar Ataxias - genetics
Spinocerebellar Ataxias - physiopathology
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Background Movement changes in autosomal‐dominant spinocerebellar ataxias are suggested to occur many years before clinical manifestation. Detecting and quantifying these changes in the preclinical phase offers a window for future treatment interventions and allows the clinician to decipher the earliest dysfunctions starting the evolution of spinocerebellar ataxia. We hypothesized that quantitative movement analysis of complex stance and gait tasks allows to (i) reveal movement changes already at early stages of the preclinical phase when clinical ataxia signs are still absent and to (ii) quantify motor progression in this phase. Methods A total of 46 participants (14 preclinical spinocerebellar ataxia mutation carriers [spinocerebellar ataxias 1,2,3,6], 9 spinocerebellar ataxia patients at an early stage; 23 healthy controls) were assessed by quantitative movement analyses of increasingly complex stance and walking tasks in a cross‐sectional design. Results Body sway in stance and spatiotemporal variability in tandem walking differentiated between preclinical mutation carriers and healthy controls (P 
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.26835