A survey of neuroimmune changes in pregnant and postpartum female rats

Highlights • Microglial density and numbers are reduced during the peripartum period. • Peripartum hippocampus, cortex, amygdala and accumbens exhibit microglial changes. • Microglia proliferation is reduced in the postpartum hippocampus. • Hippocampal IL-6 and IL-10 are increased postpartum....

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2017-01, Vol.59, p.67-78
Main Authors: Haim, Achikam, Julian, Dominic, Albin-Brooks, Christopher, Brothers, Holly M, Lenz, Kathryn M, Leuner, Benedetta
Format: Article
Language:English
Subjects:
Allergy and Immunology
Amygdala
Animals
Apoptosis
Brain - cytology
Brain - immunology
Brain Chemistry
Calcium-Binding Proteins - biosynthesis
Calcium-Binding Proteins - genetics
Cell Count
Cell Proliferation
Cytokine
Cytokines - metabolism
Female
Hippocampus
IL-10
IL-6
Immunohistochemistry
Interleukin-10 - biosynthesis
Interleukin-10 - genetics
Interleukin-6 - biosynthesis
Interleukin-6 - genetics
Maternal
Microfilament Proteins - biosynthesis
Microfilament Proteins - genetics
Microglia
Microglia - immunology
Mood
Nucleus accumbens
Postpartum
Postpartum Period - immunology
Prefrontal cortex
Pregnancy
Pregnancy, Animal - immunology
Psychiatry
Psychoneuroimmunology
Rats
Rats, Sprague-Dawley
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Summary:Highlights • Microglial density and numbers are reduced during the peripartum period. • Peripartum hippocampus, cortex, amygdala and accumbens exhibit microglial changes. • Microglia proliferation is reduced in the postpartum hippocampus. • Hippocampal IL-6 and IL-10 are increased postpartum.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.09.026