Associations between OPG and RANKL polymorphisms, vertebral fractures, and abdominal aortic calcification in community-dwelling older subjects: the Sao Paulo Ageing & Health Study (SPAH)

Summary This is the first study analyzing concomitantly osteoprotegerin ( OPG ) / receptor activator of nuclear factor kappa B ligand ( RANKL ) polymorphisms and OPG/RANKL serum levels and their association with bone mineral density (BMD), vertebral fractures, and vascular aortic calcification in a...

Full description

Saved in:
Bibliographic Details
Published in:Osteoporosis international 2016-11, Vol.27 (11), p.3319-3329
Main Authors: Pereira, R. M. R., Figueiredo, C. P., Cha, C. C., Caparbo, V. F., Oliveira, R. M., Franco, A. S., Menezes, P. R., de Castro, I., Onuchic, L. F.
Format: Article
Language:English
Subjects:
Aged
Aging
Alleles
Aorta
Aorta - pathology
Bone Density
Bone mineral density
Brazil
Calcification
Calcification (ectopic)
Calcinosis - pathology
Data processing
Endocrinology
Female
Fractures
Gene frequency
Genotypes
Humans
Male
Medicine
Medicine & Public Health
Original Article
Orthopedics
Osteoclastogenesis
Osteoporosis
Osteoprotegerin
Osteoprotegerin - blood
Osteoprotegerin - genetics
Polymorphism
Polymorphism, Single Nucleotide
Radiography
RANK Ligand - blood
RANK Ligand - genetics
Rheumatology
Risk factors
Serum levels
Single-nucleotide polymorphism
Spinal Fractures - genetics
Spine
TRANCE protein
Vertebrae
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary This is the first study analyzing concomitantly osteoprotegerin ( OPG ) / receptor activator of nuclear factor kappa B ligand ( RANKL ) polymorphisms and OPG/RANKL serum levels and their association with bone mineral density (BMD), vertebral fractures, and vascular aortic calcification in a cohort of 800 subjects in community-dwelling older individuals. Introduction Osteoprotegerin (OPG) and RANKL play an important role in osteoclast activation and differentiation as well as in vascular calcification. At present, there are no studies of OPG or RANKL gene polymorphisms in Brazilian older populations. The aim of this study was to evaluate OPG/RANKL polymorphism and their association with vertebral fractures (VFs) and aortic calcification. Methods Eight hundred subjects (497 women/303 men) were genotyped for the OPG 1181G>C (rs2073618), 163C>T (rs3102735), 245T>G (rs3134069), and 209G>A (rs3134070) and RANKL A>G (rs2277438) single-nucleotide polymorphisms (SNPs). VFs were evaluated by spine radiography (Genant’s method). Aortic calcification was quantified using Kauppila’s method. Results The isolated genotype analyses and single-allele frequency data showed association of OPG 163C, 245G, and 209A alleles with presence of VFs ( P  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-016-3664-x