Modern Approaches to Studies of New Osteogenic Biomaterials on the Model of Regeneration of Critical-Size Cranial Defects in Rats

Osteoinductive characteristics of new osteoplastic materials based on demineralized bone matrix of xenogenic origin with high and controlled degree of purification were studied on the model of regeneration of critical-size cranial defects in rats using modern approaches, including histological analy...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-12, Vol.162 (2), p.273-276
Main Authors: Bartov, M. S., Gromov, A. V., Poponova, M. S., Savina, D. M., Nikitin, K. E., Grunina, T. M., Manskikh, V. N., Gra, O. A., Lunin, V. G., Karyagina, A. S., Gintsburg, A. L.
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - pharmacology
Biological products
Biomedical and Life Sciences
Biomedicine
Bone Demineralization Technique - methods
Bone growth
Bone matrix
Bone morphogenetic protein 2
Bone Morphogenetic Protein 2 - biosynthesis
Bone Morphogenetic Protein 2 - genetics
Bone Morphogenetic Protein 2 - pharmacology
Bone Regeneration - drug effects
Bones
Cell Biology
Computed tomography
Escherichia coli - genetics
Escherichia coli - metabolism
Fluorescent Dyes
Gene Expression
Growth rate
Humans
Immobilized Proteins - biosynthesis
Immobilized Proteins - genetics
Immobilized Proteins - pharmacology
Internal Medicine
Laboratory Medicine
Male
Osteogenesis
Osteogenesis - drug effects
Pathology
Protein Multimerization
Purification
Rats
Rats, Wistar
Recombinant Proteins - biosynthesis
Recombinant Proteins - genetics
Recombinant Proteins - pharmacology
Regeneration
Skull
Skull - drug effects
Skull - injuries
Skull - surgery
Tissue Engineering
Tissue Scaffolds
X-Ray Microtomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Osteoinductive characteristics of new osteoplastic materials based on demineralized bone matrix of xenogenic origin with high and controlled degree of purification were studied on the model of regeneration of critical-size cranial defects in rats using modern approaches, including histological analysis, evaluation of morphological parameters of the bone tissue obtained by micro-computed tomography, and estimation of bone tissue growth rate using in vivo fluorochrome label. Demineralized bone matrix and, to a much greater extent, its activated form containing modified recombinant growth factor rhBMP-2 with high content of the dimeric form exhibited osteoinductive activity.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3593-x