Adipokines, tumor necrosis factor and its receptors in female patients with systemic lupus erythematosus

• Published in: Lupus 2017-01, Vol.26 (1), p.10-16
• Main Authors: Santos, F M M, Telles, R W, Lanna, C C D, Teixeira, A L, Miranda, A S, Rocha, N P, Ribeiro, A L
• Format: Article
• Language: English
• Subjects: Adipokines - metabolism; Adult; Antimalarials - administration & dosage; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Gangrene; Humans; Leptin - metabolism; Lupus; Lupus Erythematosus, Systemic - physiopathology; Lupus Nephritis - physiopathology; Middle Aged; Receptors, Tumor Necrosis Factor, Type I - metabolism; Receptors, Tumor Necrosis Factor, Type II - metabolism; Resistin - metabolism; Severity of Illness Index; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF
• ISSN: 0961-2033; 1477-0962
• DOI: 10.1177/0961203316646463

Objectives To analyze the association of adipokines and tumor necrosis factor α (TNFα) and its receptors with characteristics of systemic lupus erythematosus (SLE) and to investigate the correlation between adipokines and the TNF system. Methods One hundred and thirty-six SLE women, aged ≥18 years old, were assessed. TNFα, soluble TNFα receptors 1 (sTNFR1) and 2 (sTNFR2) and adipokines were analyzed by ELISA kits. Results The median (IQR) of age was 41.5 (33.0–49.7) years old and of disease duration 11.3 (7.8–15.8) years. The median (IQR) of disease activity was 0 (0–4) and of damage index was 2 (1–3). Higher levels of sTNFR1 and sTNFR2 were associated with nephritis (p