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Adipokines, tumor necrosis factor and its receptors in female patients with systemic lupus erythematosus
Objectives To analyze the association of adipokines and tumor necrosis factor α (TNFα) and its receptors with characteristics of systemic lupus erythematosus (SLE) and to investigate the correlation between adipokines and the TNF system. Methods One hundred and thirty-six SLE women, aged ≥18 years o...
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| Published in: | Lupus 2017-01, Vol.26 (1), p.10-16 |
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| creator | Santos, F M M Telles, R W Lanna, C C D Teixeira, A L Miranda, A S Rocha, N P Ribeiro, A L |
| description | Objectives
To analyze the association of adipokines and tumor necrosis factor α (TNFα) and its receptors with characteristics of systemic lupus erythematosus (SLE) and to investigate the correlation between adipokines and the TNF system.
Methods
One hundred and thirty-six SLE women, aged ≥18 years old, were assessed. TNFα, soluble TNFα receptors 1 (sTNFR1) and 2 (sTNFR2) and adipokines were analyzed by ELISA kits.
Results
The median (IQR) of age was 41.5 (33.0–49.7) years old and of disease duration 11.3 (7.8–15.8) years. The median (IQR) of disease activity was 0 (0–4) and of damage index was 2 (1–3). Higher levels of sTNFR1 and sTNFR2 were associated with nephritis (p |
| doi_str_mv | 10.1177/0961203316646463 |
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To analyze the association of adipokines and tumor necrosis factor α (TNFα) and its receptors with characteristics of systemic lupus erythematosus (SLE) and to investigate the correlation between adipokines and the TNF system.
Methods
One hundred and thirty-six SLE women, aged ≥18 years old, were assessed. TNFα, soluble TNFα receptors 1 (sTNFR1) and 2 (sTNFR2) and adipokines were analyzed by ELISA kits.
Results
The median (IQR) of age was 41.5 (33.0–49.7) years old and of disease duration 11.3 (7.8–15.8) years. The median (IQR) of disease activity was 0 (0–4) and of damage index was 2 (1–3). Higher levels of sTNFR1 and sTNFR2 were associated with nephritis (p < 0.001 for both), and sTNFR1 (p = 0.025) and TNFα (p = 0.014) were positively associated with arthritis. Higher sTNFR1 levels were found in participants that were not using antimalarial drugs (p = 0.04). Independent correlation was found between sTNFR1 (β = 0.253; p = 0.003) and sTNFR2 (β = 0.297; p < 0.001) levels and disease activity and damage index (sTNFR1: β = 0.367; p < 0.001; sTNFR2: β = 0.335; p < 0.001). Higher adiponectin levels were independently associated with nephritis (p = 0.009) and antimalarial drugs use (p = 0.015). There was a positive correlation between leptin and sTNFR2 levels (p = 0.002) and between resistin levels and sTNFR1 (p < 0.001) and sTNFR2 (p < 0.001).
Conclusion
The correlation between adipokines and TNF system allows a better understanding of the role of adipokines in the inflammatory response in SLE patients.]]></description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203316646463</identifier><identifier>PMID: 27365371</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adipokines - metabolism ; Adult ; Antimalarials - administration & dosage ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Gangrene ; Humans ; Leptin - metabolism ; Lupus ; Lupus Erythematosus, Systemic - physiopathology ; Lupus Nephritis - physiopathology ; Middle Aged ; Receptors, Tumor Necrosis Factor, Type I - metabolism ; Receptors, Tumor Necrosis Factor, Type II - metabolism ; Resistin - metabolism ; Severity of Illness Index ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factor-TNF</subject><ispartof>Lupus, 2017-01, Vol.26 (1), p.10-16</ispartof><rights>The Author(s) 2016</rights><rights>The Author(s) 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-f3433cf8a9b7bc6fd5c48e05562d16fbfc2b4346d9fc7c4ff7b15dbc06e0eb263</citedby><cites>FETCH-LOGICAL-c398t-f3433cf8a9b7bc6fd5c48e05562d16fbfc2b4346d9fc7c4ff7b15dbc06e0eb263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27365371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santos, F M M</creatorcontrib><creatorcontrib>Telles, R W</creatorcontrib><creatorcontrib>Lanna, C C D</creatorcontrib><creatorcontrib>Teixeira, A L</creatorcontrib><creatorcontrib>Miranda, A S</creatorcontrib><creatorcontrib>Rocha, N P</creatorcontrib><creatorcontrib>Ribeiro, A L</creatorcontrib><title>Adipokines, tumor necrosis factor and its receptors in female patients with systemic lupus erythematosus</title><title>Lupus</title><addtitle>Lupus</addtitle><description><![CDATA[Objectives
To analyze the association of adipokines and tumor necrosis factor α (TNFα) and its receptors with characteristics of systemic lupus erythematosus (SLE) and to investigate the correlation between adipokines and the TNF system.
Methods
One hundred and thirty-six SLE women, aged ≥18 years old, were assessed. TNFα, soluble TNFα receptors 1 (sTNFR1) and 2 (sTNFR2) and adipokines were analyzed by ELISA kits.
Results
The median (IQR) of age was 41.5 (33.0–49.7) years old and of disease duration 11.3 (7.8–15.8) years. The median (IQR) of disease activity was 0 (0–4) and of damage index was 2 (1–3). Higher levels of sTNFR1 and sTNFR2 were associated with nephritis (p < 0.001 for both), and sTNFR1 (p = 0.025) and TNFα (p = 0.014) were positively associated with arthritis. Higher sTNFR1 levels were found in participants that were not using antimalarial drugs (p = 0.04). Independent correlation was found between sTNFR1 (β = 0.253; p = 0.003) and sTNFR2 (β = 0.297; p < 0.001) levels and disease activity and damage index (sTNFR1: β = 0.367; p < 0.001; sTNFR2: β = 0.335; p < 0.001). Higher adiponectin levels were independently associated with nephritis (p = 0.009) and antimalarial drugs use (p = 0.015). There was a positive correlation between leptin and sTNFR2 levels (p = 0.002) and between resistin levels and sTNFR1 (p < 0.001) and sTNFR2 (p < 0.001).
Conclusion
The correlation between adipokines and TNF system allows a better understanding of the role of adipokines in the inflammatory response in SLE patients.]]></description><subject>Adipokines - metabolism</subject><subject>Adult</subject><subject>Antimalarials - administration & dosage</subject><subject>Cross-Sectional Studies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gangrene</subject><subject>Humans</subject><subject>Leptin - metabolism</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - physiopathology</subject><subject>Lupus Nephritis - physiopathology</subject><subject>Middle Aged</subject><subject>Receptors, Tumor Necrosis Factor, Type I - metabolism</subject><subject>Receptors, Tumor Necrosis Factor, Type II - metabolism</subject><subject>Resistin - metabolism</subject><subject>Severity of Illness Index</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor necrosis factor-TNF</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkc1LHTEUxUOp1Kft3lUJdNOFo_maZGYpYlUQ3Oh6yGRu-qLz1dwM8v77Zni2FEEoWYTc87vnknsIOeHsjHNjzlmtuWBScq1VPvID2XBlTJHr4iPZrHKx6ofkCPGJMSZ5rT-RQ2GkLqXhG7K96MI8PYcR8JSmZZgiHcHFCQNSb13Kbzt2NCSkERzMuYA0jNTDYHugs00Bxiy-hLSluMMEQ3C0X-YFKcRd2mYuTbjgZ3LgbY_w5fU-Jo8_rh4ub4q7--vby4u7wsm6SoWXSkrnK1u3pnXad6VTFbCy1KLj2rfeiVZJpbvaO-OU96blZdc6poFBK7Q8Jt_3vnOcfi2AqRkCOuh7O8K0YMOrsmRV3lr1H6jQhpmyXl2_vUGfpiWO-SOZUpVRUhiRKban1gViBN_MMQw27hrOmjWw5m1gueXrq_HSDtD9bfiTUAaKPYD2J_wz9T3D3xwGnqI</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Santos, F M M</creator><creator>Telles, R W</creator><creator>Lanna, C C D</creator><creator>Teixeira, A L</creator><creator>Miranda, A S</creator><creator>Rocha, N P</creator><creator>Ribeiro, A L</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201701</creationdate><title>Adipokines, tumor necrosis factor and its receptors in female patients with systemic lupus erythematosus</title><author>Santos, F M M ; Telles, R W ; Lanna, C C D ; Teixeira, A L ; Miranda, A S ; Rocha, N P ; Ribeiro, A L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-f3433cf8a9b7bc6fd5c48e05562d16fbfc2b4346d9fc7c4ff7b15dbc06e0eb263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipokines - metabolism</topic><topic>Adult</topic><topic>Antimalarials - administration & dosage</topic><topic>Cross-Sectional Studies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gangrene</topic><topic>Humans</topic><topic>Leptin - metabolism</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - physiopathology</topic><topic>Lupus Nephritis - physiopathology</topic><topic>Middle Aged</topic><topic>Receptors, Tumor Necrosis Factor, Type I - metabolism</topic><topic>Receptors, Tumor Necrosis Factor, Type II - metabolism</topic><topic>Resistin - metabolism</topic><topic>Severity of Illness Index</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santos, F M M</creatorcontrib><creatorcontrib>Telles, R W</creatorcontrib><creatorcontrib>Lanna, C C D</creatorcontrib><creatorcontrib>Teixeira, A L</creatorcontrib><creatorcontrib>Miranda, A S</creatorcontrib><creatorcontrib>Rocha, N P</creatorcontrib><creatorcontrib>Ribeiro, A L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santos, F M M</au><au>Telles, R W</au><au>Lanna, C C D</au><au>Teixeira, A L</au><au>Miranda, A S</au><au>Rocha, N P</au><au>Ribeiro, A L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adipokines, tumor necrosis factor and its receptors in female patients with systemic lupus erythematosus</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2017-01</date><risdate>2017</risdate><volume>26</volume><issue>1</issue><spage>10</spage><epage>16</epage><pages>10-16</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract><![CDATA[Objectives
To analyze the association of adipokines and tumor necrosis factor α (TNFα) and its receptors with characteristics of systemic lupus erythematosus (SLE) and to investigate the correlation between adipokines and the TNF system.
Methods
One hundred and thirty-six SLE women, aged ≥18 years old, were assessed. TNFα, soluble TNFα receptors 1 (sTNFR1) and 2 (sTNFR2) and adipokines were analyzed by ELISA kits.
Results
The median (IQR) of age was 41.5 (33.0–49.7) years old and of disease duration 11.3 (7.8–15.8) years. The median (IQR) of disease activity was 0 (0–4) and of damage index was 2 (1–3). Higher levels of sTNFR1 and sTNFR2 were associated with nephritis (p < 0.001 for both), and sTNFR1 (p = 0.025) and TNFα (p = 0.014) were positively associated with arthritis. Higher sTNFR1 levels were found in participants that were not using antimalarial drugs (p = 0.04). Independent correlation was found between sTNFR1 (β = 0.253; p = 0.003) and sTNFR2 (β = 0.297; p < 0.001) levels and disease activity and damage index (sTNFR1: β = 0.367; p < 0.001; sTNFR2: β = 0.335; p < 0.001). Higher adiponectin levels were independently associated with nephritis (p = 0.009) and antimalarial drugs use (p = 0.015). There was a positive correlation between leptin and sTNFR2 levels (p = 0.002) and between resistin levels and sTNFR1 (p < 0.001) and sTNFR2 (p < 0.001).
Conclusion
The correlation between adipokines and TNF system allows a better understanding of the role of adipokines in the inflammatory response in SLE patients.]]></abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>27365371</pmid><doi>10.1177/0961203316646463</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Lupus, 2017-01, Vol.26 (1), p.10-16 |
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| subjects | Adipokines - metabolism Adult Antimalarials - administration & dosage Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Female Gangrene Humans Leptin - metabolism Lupus Lupus Erythematosus, Systemic - physiopathology Lupus Nephritis - physiopathology Middle Aged Receptors, Tumor Necrosis Factor, Type I - metabolism Receptors, Tumor Necrosis Factor, Type II - metabolism Resistin - metabolism Severity of Illness Index Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF |
| title | Adipokines, tumor necrosis factor and its receptors in female patients with systemic lupus erythematosus |
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