N-terminal pro-brain natriuretic peptide can be an adjunctive diagnostic marker of hyper-acute phase of Kawasaki disease

• Published in: European journal of pediatrics 2016-12, Vol.175 (12), p.1997-2003
• Main Authors: Kwon, Hyuksool, Lee, Jin Hee, Jung, Jae Yun, Kwak, Young Ho, Kim, Do Kyun, Jung, Jin Hee, Chang, Ikwan, Kim, Kyuseok
• Format: Article
• Language: English
• Subjects: Acute Disease; Age; Biomarkers - blood; Child; Child, Preschool; Data warehouses; Diagnosis, Differential; Emergency medical care; Female; Fever; Fever - etiology; Hospitals; Humans; Infant; Kawasaki disease; Laboratories; Male; Medical records; Medicine; Medicine & Public Health; Mucocutaneous Lymph Node Syndrome - blood; Mucocutaneous Lymph Node Syndrome - diagnosis; Natriuretic Peptide, Brain - blood; Original Article; Pediatrics; Peptide Fragments - blood; Peptides; Retrospective Studies; ROC Curve; Sensitivity and Specificity
• ISSN: 0340-6199; 1432-1076
• DOI: 10.1007/s00431-016-2798-3

The purpose of this study was to determine whether the serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level could be a useful marker for Kawasaki disease in the pediatric emergency department (PED) and in the presence of fever duration of 4 days or less (hyper-acute phase of Kawasaki disease). Medical records of patients who were 1 month to 15 years old of age and presented at the PED with suspected Kawasaki disease from January 1, 2010, to December 31, 2014, were collected retrospectively. Two hundred thirty-nine patients with a history of fever for 4 days or less were diagnosed with Kawasaki disease, as well as 111 patients with other febrile diseases, and were enrolled. The NT-proBNP level was significantly higher in patients with Kawasaki disease (Kawasaki disease vs. other febrile disease group, 444.8 (189.7–951.5) vs. 153.4 (68.9–287.6) pg/mL; p