MicroRNA expression profiling in Guillain-Barré syndrome

Abstract Guillain-Barré syndrome (GBS) is an acute inflammatory autoimmune disease affecting the peripheral nervous system. MicroRNAs (miRNAs) are a class of small noncoding RNAs that play critical roles in the process of various diseases. The miRNAs in GBS were less studied. In this study, using mi...

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Bibliographic Details
Published in:Journal of neuroimmunology 2016-12, Vol.301, p.12-15
Main Authors: Lv, Zhanyun, Shi, Qiguang, Huang, Wenhui, Xing, Chunye, Hao, Yanlei, Feng, Xungang, Yang, Yan, Zhang, Aimei, Kong, Qingxia, Yuki, Nobuhiro, Wang, Yuzhong
Format: Article
Language:English
Subjects:
Allergy and Immunology
Case-Control Studies
Female
Gene Expression Profiling
Gene Regulatory Networks
Guillain-Barre Syndrome - genetics
Guillain-Barre Syndrome - metabolism
Guillain-Barré syndrome
Humans
Male
Microarray Analysis
MicroRNAs - genetics
MicroRNAs - metabolism
miR-4717
miR-642b
miRNAs
Neurology
RNA, Messenger - metabolism
Up-Regulation - physiology
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Summary:Abstract Guillain-Barré syndrome (GBS) is an acute inflammatory autoimmune disease affecting the peripheral nervous system. MicroRNAs (miRNAs) are a class of small noncoding RNAs that play critical roles in the process of various diseases. The miRNAs in GBS were less studied. In this study, using microarray technology, we found two miRNAs including has-miR-4717-5p and has-miR-642b-5p were upregulated in patients with GBS, which were further confirmed by PCR analysis. Kyoto Encyclopedia of Genes and Genomes pathway analysis suggested that the dysregulated miRNAs may be involved in the mechanism of GBS by affecting the cellular differentiation, cell survival and axonal outgrowth.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2016.10.014