Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation-Induced Emission for Evaluation of Blood-Brain Barrier Damage

Detection of damage to the blood–brain barrier (BBB) is important for the diagnosis of brain diseases and therapeutic drug evaluation. The widely used probe, Evans blue, suffers from low specificity and high toxicity in vivo. It is shown that organic nanoparticles with tuneable size, good biocompati...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2016-10, Vol.28 (39), p.8760-8765
Main Authors: Cai, Xiaolei, Bandla, Aishwarya, Mao, Duo, Feng, Guangxue, Qin, Wei, Liao, Lun-De, Thakor, Nitish, Tang, Ben Zhong, Liu, Bin
Format: Article
Language:English
Subjects:
aggregation-induced emission
Biocompatibility
Blood-brain barrier
blood-brain barrier damage
Brain
Damage detection
Emission
Ischemia
Nanoparticles
photothrombotic ischemia
stroke
Toxicity
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Summary:Detection of damage to the blood–brain barrier (BBB) is important for the diagnosis of brain diseases and therapeutic drug evaluation. The widely used probe, Evans blue, suffers from low specificity and high toxicity in vivo. It is shown that organic nanoparticles with tuneable size, good biocompatibility, and aggregation‐induced emission characteristics offer high detection specificity to detect BBB damage via a photothrombotic ischemia rat model.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201601191