Exploiting Noncovalent Interactions in an Imine-Based Covalent Organic Framework for Quercetin Delivery

Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug‐delivery vehicles with high loading capacity and biocompatibility. The interaction between the carrier and the cargo is specifically tailored on a molecular level by H‐bonding. Cell‐proliferatio...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2016-10, Vol.28 (39), p.8749-8754
Main Authors: Vyas, Vijay S., Vishwakarma, Medhavi, Moudrakovski, Igor, Haase, Frederik, Savasci, Gökcen, Ochsenfeld, Christian, Spatz, Joachim P., Lotsch, Bettina V.
Format: Article
Language:English
Subjects:
Bearing strength
Biocompatibility
Cancer
Covalence
covalent organic frameworks
drug delivery
Drug delivery systems
Effectiveness
molecular dynamics
Nanostructure
porous materials
supramolecular chemistry
Vehicles
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Summary:Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug‐delivery vehicles with high loading capacity and biocompatibility. The interaction between the carrier and the cargo is specifically tailored on a molecular level by H‐bonding. Cell‐proliferation studies indicate higher efficacy of the drug in cancer cells by nanocarrier delivery mediated by the COF.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201603006