Alkyne cellulose for Huisgen [3 + 2] cycloaddition with azido‐terminated targets

• Published in: Journal of applied polymer science 2017-01, Vol.134 (4), p.np-n/a
• Main Authors: Cao, Liangcheng, Wang, Yuechuan
• Format: Article
• Language: English
• Subjects: Alkynes; biopolymers and renewable polymers; Cellulose; cellulose and other wood products; Conversion; Cycloaddition; Esterification; Fourier transforms; grafting; Infrared spectroscopy; Materials science; NMR spectroscopy; Polymers; synthesis and processing
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.44410

ABSTRACT Azido‐grafted cellulose has been reported widely applied for further functionalization by click chemistry. As an alternative method, we proposed alkyne‐grafted cellulose as a prototype molecule for Huisgen [3 + 2] cycloaddition with azido‐terminated target compounds. Alkyne cellulose was synthesized by acylation with prop‐2‐ynyl 5‐chloro‐5‐oxopentanoate and, subsequently cycloaddition with 4‐aminophenylazide, ethyl 2‐azidoacetate, and (S)‐2‐(Azidomethyl)‐1‐(tert‐butoxycarbonyl)pyrrolidine (Boc‐pyrrolidine azide) to form triazole cellulose in a click manner. The reactions were confirmed qualitatively by Fourier transform infrared and NMR spectroscopy and analyzed quantitatively with elemental analysis data. The results show that a degree of substitution of up to 1.91 was obtained for esterification and, in most cases, was preferred completely in a selective way for the primary hydroxyl groups at the O‐6 position and partially at the O‐2 and O‐3 positions. Cycloaddition conversions were found as high as 0.95, 0.99, and 0.99 for aniline–triazole cellulose, acetate–triazole cellulose, and Boc‐pyrrolidine‐triazole cellulose, respectively. Both esterification and cycloaddition were undertaken under mild conditions without additional heating. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44410.