Amphiphilic BODIPY derivatives: the solvophobic effect on their photophysical properties and bioimaging in living cells

Three novel amphiphilic BODIPY derivatives were prepared and their photophysical properties in THF/water mixtures with varying fractions of water were investigated. BDP-1 could self-assemble into different vesicle architectures in aqueous solution, while BDP-2 and BDP-3 with more hydrophilic abiliti...

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Bibliographic Details
Published in:Soft matter 2016-01, Vol.12 (41), p.8581-8587
Main Authors: Yang, Lan, Ji, Ya-Jian, Yin, Jia-Fu, Wu, Yongquan, Fan, Haiming, Zhang, Yi, Kuang, Gui-Chao
Format: Article
Language:English
Subjects:
Boron Compounds - chemistry
Cells (biology)
Derivatives
Fluorescent Dyes
HeLa Cells
Humans
Imaging
Lysosomes
Lysosomes - chemistry
Micelles
Nanostructure
Organelles
Toxicity
Vesicles
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Summary:Three novel amphiphilic BODIPY derivatives were prepared and their photophysical properties in THF/water mixtures with varying fractions of water were investigated. BDP-1 could self-assemble into different vesicle architectures in aqueous solution, while BDP-2 and BDP-3 with more hydrophilic abilities formed spherical and worm-like micelles. The BODIPY derivatives could be absorbed by HeLa cells and showed no apparent toxicity during the course of the test. In particular, unlike traditional amines or morpholinyl functionalized lysosome fluorescent probes, BDP-1 nanovesicles without targeted groups exhibit red emission and show effective lysosome biological imaging. Co-staining experiments with lysosome specific trackers further confirmed the disassembly of BDP-1 nanovesicles in lysosomes. This research provides a new avenue of using probes without targeting the structural unit to stain special organelles and shows potential applications in cell imaging fields.
ISSN:1744-683X
1744-6848
DOI:10.1039/c6sm01796g