Two-dimensional metal-organic framework nanosheets as a matrix for laser desorption/ionization of small molecules and monitoring enzymatic reactions at high salt concentrations

Stable 2-D metal-organic framework nanosheets were utilized as a superior clean-background matrix for MALDI-TOF MS analysis of small biomolecules and pollutants in both positive and negative ion modes. The matrix could unusually afford up to 1000 mM of the salt concentrations in the monitoring of th...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (88), p.12984-12987
Main Authors: Liu, Hai-Long, Chang, Yu-Jie, Fan, Ting, Gu, Zhi-Yuan
Format: Article
Language:English
Subjects:
Hydrolysis
Ionization
Lasers
Metal-organic frameworks
Monitoring
Nanostructure
Neurotransmitters
Pollutants
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Summary:Stable 2-D metal-organic framework nanosheets were utilized as a superior clean-background matrix for MALDI-TOF MS analysis of small biomolecules and pollutants in both positive and negative ion modes. The matrix could unusually afford up to 1000 mM of the salt concentrations in the monitoring of the enzymatic hydrolysis of neurotransmitter acetylcholine.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc07371a