Installing tungsten Fischer carbene complexes into a calixarene framework

The synthesis of the first examples of calix[4]arene-based Fischer carbene complexes is reported here. Fischer carbene complex 2 is the key intermediate to reach uracil-like derivatives 3 and 4 . X-ray and NMR studies revealed that the uracyl-like synthon gives rise to a supramolecular dimer. The or...

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Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (78), p.75002-75005
Main Authors: D'Acunto, M., Tommasone, S., Talotta, C., Brancatelli, G., Geremia, S., Valletta, E., Marino Merlo, F., Macchi, B., Gaeta, C., Neri, P., Spinella, A.
Format: Article
Language:English
Subjects:
Biotechnology
Calixarenes
Carbenes
Derivatives
Dimers
Metalorganic compounds
Toxicity
X-rays
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Summary:The synthesis of the first examples of calix[4]arene-based Fischer carbene complexes is reported here. Fischer carbene complex 2 is the key intermediate to reach uracil-like derivatives 3 and 4 . X-ray and NMR studies revealed that the uracyl-like synthon gives rise to a supramolecular dimer. The organometallic calixarene complexes showed a promising cytotoxicity towards human tumor cell lines.
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA17326H