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Network meta‐analysis of probiotics to prevent respiratory infections in children and adolescents
Summary Probiotics have emerged as a promising intervention for the prevention of respiratory tract infections (RTIs) in children. Assess the effect of probiotics on prevention of RTIs in children and adolescents. MEDLINE, EMBASE, LILACS, SCIELO, CINAHL, SCOPUS, and Web of Science. Key words: “respi...
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Published in: | Pediatric pulmonology 2017-06, Vol.52 (6), p.833-843 |
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creator | Amaral, Marina Azambuja Guedes, Gabriela Helena Barbosa Ferreira Epifanio, Matias Wagner, Mario Bernardes Jones, Marcus Herbert Mattiello, Rita |
description | Summary
Probiotics have emerged as a promising intervention for the prevention of respiratory tract infections (RTIs) in children. Assess the effect of probiotics on prevention of RTIs in children and adolescents. MEDLINE, EMBASE, LILACS, SCIELO, CINAHL, SCOPUS, and Web of Science. Key words: “respiratory tract infections” AND probiotics. Randomized controlled trials RCT assessing the effect of probiotics on RTIs in children and adolescents were included. Two reviewers, working independently, to identify studies that met the eligibility criteria. Main and secondary outcomes were RTIs and adverse effects, respectively. Twenty‐one trials with 6.603 participants were included. Pairwise meta‐analysis suggested that Lactobacillus casei rhamnosus (LCA) was the only effective probiotic to the rate of RTIs compared to placebo (RR0.38; Crl 0.19–0.45). Network analysis showed that the LCA exhibited 54.7% probability of being classified in first, while the probability of Lactobacillus fermentum CECT5716 (LFC) being last in the ranking was 15.3%. LCA showed no better effect compared to other probiotic strains by indirect analysis. This systematic review found a lack of evidence to support the effect of probiotic on the incidence rate of respiratory infections in children and adolescents. Pediatr Pulmonol. 2017;52:833–843. © 2017 Wiley Periodicals, Inc. |
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Probiotics have emerged as a promising intervention for the prevention of respiratory tract infections (RTIs) in children. Assess the effect of probiotics on prevention of RTIs in children and adolescents. MEDLINE, EMBASE, LILACS, SCIELO, CINAHL, SCOPUS, and Web of Science. Key words: “respiratory tract infections” AND probiotics. Randomized controlled trials RCT assessing the effect of probiotics on RTIs in children and adolescents were included. Two reviewers, working independently, to identify studies that met the eligibility criteria. Main and secondary outcomes were RTIs and adverse effects, respectively. Twenty‐one trials with 6.603 participants were included. Pairwise meta‐analysis suggested that Lactobacillus casei rhamnosus (LCA) was the only effective probiotic to the rate of RTIs compared to placebo (RR0.38; Crl 0.19–0.45). Network analysis showed that the LCA exhibited 54.7% probability of being classified in first, while the probability of Lactobacillus fermentum CECT5716 (LFC) being last in the ranking was 15.3%. LCA showed no better effect compared to other probiotic strains by indirect analysis. This systematic review found a lack of evidence to support the effect of probiotic on the incidence rate of respiratory infections in children and adolescents. Pediatr Pulmonol. 2017;52:833–843. © 2017 Wiley Periodicals, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.23643</identifier><identifier>PMID: 28052594</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Child ; Humans ; Infections ; Meta-analysis ; Network Meta-Analysis ; Probiotics ; Probiotics - therapeutic use ; Randomized Controlled Trials as Topic ; respiratory tract infections ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - prevention & control ; Teenagers ; Vaccines</subject><ispartof>Pediatric pulmonology, 2017-06, Vol.52 (6), p.833-843</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4273-670625977522db2bff308a0599fee4a8bb612d865b01c97078e24486949c9d4f3</citedby><cites>FETCH-LOGICAL-c4273-670625977522db2bff308a0599fee4a8bb612d865b01c97078e24486949c9d4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28052594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amaral, Marina Azambuja</creatorcontrib><creatorcontrib>Guedes, Gabriela Helena Barbosa Ferreira</creatorcontrib><creatorcontrib>Epifanio, Matias</creatorcontrib><creatorcontrib>Wagner, Mario Bernardes</creatorcontrib><creatorcontrib>Jones, Marcus Herbert</creatorcontrib><creatorcontrib>Mattiello, Rita</creatorcontrib><title>Network meta‐analysis of probiotics to prevent respiratory infections in children and adolescents</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description>Summary
Probiotics have emerged as a promising intervention for the prevention of respiratory tract infections (RTIs) in children. Assess the effect of probiotics on prevention of RTIs in children and adolescents. MEDLINE, EMBASE, LILACS, SCIELO, CINAHL, SCOPUS, and Web of Science. Key words: “respiratory tract infections” AND probiotics. Randomized controlled trials RCT assessing the effect of probiotics on RTIs in children and adolescents were included. Two reviewers, working independently, to identify studies that met the eligibility criteria. Main and secondary outcomes were RTIs and adverse effects, respectively. Twenty‐one trials with 6.603 participants were included. Pairwise meta‐analysis suggested that Lactobacillus casei rhamnosus (LCA) was the only effective probiotic to the rate of RTIs compared to placebo (RR0.38; Crl 0.19–0.45). Network analysis showed that the LCA exhibited 54.7% probability of being classified in first, while the probability of Lactobacillus fermentum CECT5716 (LFC) being last in the ranking was 15.3%. LCA showed no better effect compared to other probiotic strains by indirect analysis. This systematic review found a lack of evidence to support the effect of probiotic on the incidence rate of respiratory infections in children and adolescents. Pediatr Pulmonol. 2017;52:833–843. © 2017 Wiley Periodicals, Inc.</description><subject>Adolescent</subject><subject>Child</subject><subject>Humans</subject><subject>Infections</subject><subject>Meta-analysis</subject><subject>Network Meta-Analysis</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Randomized Controlled Trials as Topic</subject><subject>respiratory tract infections</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - prevention & control</subject><subject>Teenagers</subject><subject>Vaccines</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kM1O3DAURq0K1BmGbngAZIlNhRRqO_5dolGhlUaUBawjx7lRPWTiYCeg2fUR-ox9Ekxn2gULVrblcz999yB0QskFJYR9GYapu2Cl5OUHNKfEmIJwIw_QXCshCqllOUNHKa0JyX-GfkQzpolgwvA5cjcwPof4gDcw2j-_ftvedtvkEw4tHmKofRi9S3gM-QVP0I84Qhp8tGOIW-z7FtzoQ5_yFbufvmsi9Nj2DbZN6CC5PJGO0WFruwSf9ucC3V99vVt-K1Y_rr8vL1eF40yVhVRE5lJKCcaamtVtWxJtiTCmBeBW17WkrNFS1IQ6o4jSwDjX0nDjTMPbcoE-73Jz8ccJ0lhtfG7QdbaHMKWKaiGUoUywjJ69Qddhinn3TJnsiatSl5k631EuhpQitNUQ_cbGbUVJ9aq-elVf_VWf4dN95FRvoPmP_nOdAboDnn0H23eiqtvb-9Uu9AXc0I_7</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Amaral, Marina Azambuja</creator><creator>Guedes, Gabriela Helena Barbosa Ferreira</creator><creator>Epifanio, Matias</creator><creator>Wagner, Mario Bernardes</creator><creator>Jones, Marcus Herbert</creator><creator>Mattiello, Rita</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Network meta‐analysis of probiotics to prevent respiratory infections in children and adolescents</title><author>Amaral, Marina Azambuja ; Guedes, Gabriela Helena Barbosa Ferreira ; Epifanio, Matias ; Wagner, Mario Bernardes ; Jones, Marcus Herbert ; Mattiello, Rita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4273-670625977522db2bff308a0599fee4a8bb612d865b01c97078e24486949c9d4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Humans</topic><topic>Infections</topic><topic>Meta-analysis</topic><topic>Network Meta-Analysis</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Randomized Controlled Trials as Topic</topic><topic>respiratory tract infections</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - prevention & control</topic><topic>Teenagers</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amaral, Marina Azambuja</creatorcontrib><creatorcontrib>Guedes, Gabriela Helena Barbosa Ferreira</creatorcontrib><creatorcontrib>Epifanio, Matias</creatorcontrib><creatorcontrib>Wagner, Mario Bernardes</creatorcontrib><creatorcontrib>Jones, Marcus Herbert</creatorcontrib><creatorcontrib>Mattiello, Rita</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amaral, Marina Azambuja</au><au>Guedes, Gabriela Helena Barbosa Ferreira</au><au>Epifanio, Matias</au><au>Wagner, Mario Bernardes</au><au>Jones, Marcus Herbert</au><au>Mattiello, Rita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Network meta‐analysis of probiotics to prevent respiratory infections in children and adolescents</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2017-06</date><risdate>2017</risdate><volume>52</volume><issue>6</issue><spage>833</spage><epage>843</epage><pages>833-843</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>Summary
Probiotics have emerged as a promising intervention for the prevention of respiratory tract infections (RTIs) in children. Assess the effect of probiotics on prevention of RTIs in children and adolescents. MEDLINE, EMBASE, LILACS, SCIELO, CINAHL, SCOPUS, and Web of Science. Key words: “respiratory tract infections” AND probiotics. Randomized controlled trials RCT assessing the effect of probiotics on RTIs in children and adolescents were included. Two reviewers, working independently, to identify studies that met the eligibility criteria. Main and secondary outcomes were RTIs and adverse effects, respectively. Twenty‐one trials with 6.603 participants were included. Pairwise meta‐analysis suggested that Lactobacillus casei rhamnosus (LCA) was the only effective probiotic to the rate of RTIs compared to placebo (RR0.38; Crl 0.19–0.45). Network analysis showed that the LCA exhibited 54.7% probability of being classified in first, while the probability of Lactobacillus fermentum CECT5716 (LFC) being last in the ranking was 15.3%. LCA showed no better effect compared to other probiotic strains by indirect analysis. This systematic review found a lack of evidence to support the effect of probiotic on the incidence rate of respiratory infections in children and adolescents. Pediatr Pulmonol. 2017;52:833–843. © 2017 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28052594</pmid><doi>10.1002/ppul.23643</doi><tpages>11</tpages></addata></record> |
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subjects | Adolescent Child Humans Infections Meta-analysis Network Meta-Analysis Probiotics Probiotics - therapeutic use Randomized Controlled Trials as Topic respiratory tract infections Respiratory Tract Infections - epidemiology Respiratory Tract Infections - prevention & control Teenagers Vaccines |
title | Network meta‐analysis of probiotics to prevent respiratory infections in children and adolescents |
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